Ribstein J, Rodier M, Mimran A
Department of Medicine, Hôpital Lapeyronie, CHU, Montpellier, France.
J Hypertens Suppl. 1989 Dec;7(6):S198-9. doi: 10.1097/00004872-198900076-00095.
The effect of cyclosporine A therapy on blood pressure and renal function was assessed in 11 young adults with type 1 diabetes of recent onset (7 +/- 1 weeks). Metabolic control and renal haemodynamics and function were evaluated at 3-month intervals before, during and after cessation of a 6-month course of cyclosporine A (initial dose 7.5 mg/kg per day, then adapted on whole-blood trough levels of 401 +/- 45 and 308 +/- 49 ng/ml at 3 and 6 months, respectively). A significant increase in blood pressure (from 117 +/- 2/65 +/- 2 to 122 +/- 2/72 +/- 3 mmHg; P less than 0.01) and a decrease in 99Tc-DTPA (diethylene triaminepentaacetic acid) clearance (124 +/- 6 to 98 +/- 5 ml/min per m2; P less than 0.01) were observed after 3 months of cyclosporine A; both alterations remained unchanged after 6 months. No variation in body weight, 24-h urinary sodium or urinary albumin excretion was observed. Blood pressure and the glomerular filtration rate returned to basal levels 3 months after the cyclosporine A therapy ceased. These results suggest that even moderate doses of cyclosporine A have a reversible deleterious effect on blood pressure and renal function in young diabetic patients.
在11名近期发病（7±1周）的1型糖尿病年轻成年人中评估了环孢素A治疗对血压和肾功能的影响。在为期6个月的环孢素A疗程之前、期间和停止后，每隔3个月评估代谢控制以及肾脏血流动力学和功能（初始剂量为每天7.5 mg/kg，然后根据3个月和6个月时全血谷浓度分别调整为401±45和308±49 ng/ml）。环孢素A治疗3个月后，观察到血压显著升高（从117±2/65±2 mmHg升至122±2/72±3 mmHg；P<0.01）以及99Tc-DTPA（二乙三胺五乙酸）清除率下降（从124±6降至98±5 ml/min per m2；P<0.01）；6个月后这两种改变均保持不变。未观察到体重、24小时尿钠或尿白蛋白排泄有变化。环孢素A治疗停止3个月后，血压和肾小球滤过率恢复至基础水平。这些结果表明，即使是中等剂量的环孢素A对年轻糖尿病患者的血压和肾功能也有可逆的有害影响。
