Hopfner Franziska, Nebel Adelheid, Lyons Kelly E, Tröster Alexander I, Kuhlenbäumer Gregor, Deuschl Günther, Martinez-Martin Pablo
a Department of Neurology , University Hospital Schleswig-Holstein , Campus Kiel , Kiel , Germany.
b Department of Neurology , University of Kansas Medical Center , Kansas City , MO , USA.
Int J Neurosci. 2016;126(2):127-34. doi: 10.3109/00207454.2015.1077241. Epub 2015 Aug 25.
To explore the clinimetric attributes of the German version of the quality of life in essential tremor (ET) questionnaire (QUEST) as a tremor-specific measure of quality of life.
This was an observational, cross-sectional study. The QUEST German version was obtained by translation-back translation procedure. ET cases were diagnosed according to the tremor investigation group criteria. Assessments included Archimedes spirals rating, EQ-5D, Beck Depression Inventory (BDI-II) and QUEST German version. Missing data were imputed for those cases in which the loss of data for one domain of the QUEST was <30%.
Ninety three patients out of 138 (67.4%) with definite or probable ET had complete QUEST data after 43 item imputations and they constituted the sample for this study. The QUEST summary index (QSI) displayed no floor or ceiling effects. QUEST internal consistency (Cronbach's alpha) ranged between 0.50 and 0.89. Item-total domain correlations ranged from 0.26 to 0.82 and the item homogeneity indexes were satisfactory (range: 0.28-0.60). The QSI correlated weakly with the EQ-5D (rS=0.20) and moderately with the BDI-II (rS = 0.31) and the QUEST self-evaluation of tremor severity (rS = 0.44).
The QUEST German version has, despite recognized data quality problems, satisfactory acceptability and internal consistency as a whole. The correlation analysis showed that tremor in the head, voice and right hand was moderately associated with quality of life.
探讨德语版特发性震颤（ET）生活质量问卷（QUEST）作为一种特定于震颤的生活质量测量工具的临床测量属性。
这是一项观察性横断面研究。德语版QUEST通过翻译-回译程序获得。ET病例根据震颤调查组标准进行诊断。评估包括阿基米德螺旋线评分、EQ-5D、贝克抑郁量表（BDI-II）和德语版QUEST。对于QUEST一个领域数据缺失<30%的病例，对缺失数据进行插补。
138例确诊或可能患有ET的患者中，93例（67.4%）在进行43项插补后有完整的QUEST数据，他们构成了本研究的样本。QUEST总结指数（QSI）未显示地板效应或天花板效应。QUEST内部一致性（克朗巴哈α系数）在0.50至0.89之间。项目-总分域相关性在0.26至0.82之间，项目同质性指数令人满意（范围：0.28 - 0.60）。QSI与EQ-5D弱相关（rS = 0.20），与BDI-II中度相关（rS = 0.31），与QUEST对震颤严重程度的自我评估中度相关（rS = 0.44）。
尽管存在公认的数据质量问题，但德语版QUEST总体上具有令人满意的可接受性和内部一致性。相关性分析表明，头部、声音和右手的震颤与生活质量中度相关。
