Area of Applied Epidemiology, National Center for Epidemiology, and Consortium for Biomedical Research in Neurodegenerative Diseases (Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas-CIBERNED), Carlos III Institute of Health, CI, Sinesio Delgado, 6, 28029 Madrid, Spain.
J Clin Epidemiol. 2010 Jul;63(7):767-73. doi: 10.1016/j.jclinepi.2009.09.001. Epub 2009 Dec 2.
This study sought to assess the psychometric attributes of the Quality of Life in Essential Tremor Questionnaire (QUEST) by undertaking an independent validation.
This was an observational, multicenter, cross-sectional study carried out in Neurology Departments of general hospitals. The following assessments were applied: Louis Rating Scale, Clinical Assessment of Tremor, Clinical Global Impression of Severity (CGI-ET), Hospital Anxiety and Depression Scale (HADS), EQ-5D, and QUEST (Spanish version).
One hundred and eighteen consecutive patients were included. According to the CGI-ET, most of patients had mild (42.4%) or moderate (43.2%) impact of tremor on performing daily activities. Fully computable QUEST data were 60.2%. The QUEST Summary Index (QUEST-SI) displayed marginal floor or ceiling effect. On the whole, QUEST internal consistency and reproducibility were satisfactory (Cronbach's alpha values: 0.73-0.86; QUEST-SI intraclass correlation coefficient: 0.77). Factor analysis identified eight factors (73.6% of the variance) that could be grouped into six, relatively coincident with the questionnaire's dimensions. The QUEST-SI correlated moderately with the EQ-5D index (r(S)=-0.40), HADS-Depression (r(S)=0.39), and CGI-ET (r(S)=0.39), and strongly with the QUEST scale for self-evaluation of tremor severity (r(S)=0.63). The standard error of measurement was 8.00.
Apart from a substantial problem of acceptability, most of the tested psychometric attributes of the QUEST resulted satisfactory.
通过独立验证，评估原发性震颤生活质量问卷（QUEST）的心理测量特性。
这是一项在综合医院神经科进行的观察性、多中心、横断面研究。应用了以下评估方法：路易氏评定量表、震颤临床评估、震颤严重程度临床总体印象（CGI-ET）、医院焦虑和抑郁量表（HADS）、EQ-5D 和 QUEST（西班牙语版）。
共纳入 118 例连续患者。根据 CGI-ET，大多数患者的震颤对日常活动的影响为轻度（42.4%）或中度（43.2%）。可计算的 QUEST 完整数据为 60.2%。QUEST 综合指数（QUEST-SI）显示出轻微的下限或上限效应。总的来说，QUEST 的内部一致性和可重复性令人满意（Cronbach's alpha 值：0.73-0.86；QUEST-SI 组内相关系数：0.77）。因子分析确定了 8 个因素（占方差的 73.6%），可分为 6 组，与问卷的维度相对一致。QUEST-SI 与 EQ-5D 指数（r(S)=-0.40）、HADS 抑郁量表（r(S)=0.39）和 CGI-ET（r(S)=0.39）中度相关，与 QUEST 震颤严重程度自评量表（r(S)=0.63）高度相关。测量的标准误差为 8.00。
除了可接受性的实质性问题外，QUEST 的大多数测试心理测量特性均令人满意。
