Bobylev I, Elter T, Schneider C, Wunderlich G, Zimmer P, Streckmann F, Fink G R, Lehmann H C
Klinik und Poliklinik für Neurologie, Universitätsklinikum Köln.
Klinik für Innere Medizin I, Universitätsklinikum Köln.
Fortschr Neurol Psychiatr. 2015 Aug;83(8):427-36. doi: 10.1055/s-0035-1553475. Epub 2015 Sep 1.
Chemotherapy-induced peripheral neuropathy (CIPN) is a common and relevant side effect of antineoplastic agents such as cisplatin, paclitaxel, vincristine and bortezomib. Over the last years, significant progress has been achieved in elucidating the underlying pathomechanisms of CIPN using both in vivo and in vitro models. These studies suggest that mitochondrial toxicity, disturbed axonal transport, toxic effects on Schwann cells and activation of the immune system contribute to the pathogenesis of CIPN. This review provides an overview of the current pathogenetic concepts of CIPN. In addition, experimental approaches that aim at preventing or ameliorating neurotoxic effects of antineoplastic agents are discussed.
化疗引起的周围神经病变（CIPN）是顺铂、紫杉醇、长春新碱和硼替佐米等抗肿瘤药物常见且相关的副作用。在过去几年中，利用体内和体外模型在阐明CIPN的潜在发病机制方面取得了重大进展。这些研究表明，线粒体毒性、轴突运输紊乱、对施万细胞的毒性作用以及免疫系统的激活都有助于CIPN的发病机制。本综述概述了CIPN目前的发病机制概念。此外，还讨论了旨在预防或减轻抗肿瘤药物神经毒性作用的实验方法。
