Kong Ling-Na, Guo Ying, Qin Bo, Peng Xin, Zhu Wen-Fen
Department of Infectious Diseases, the First Affiliated Hospital of Chongqing Medical University, Chongqing, PR China.
Department of Internal Medicine, Outpatient Department, the Second Affiliated Hospital of Harbin Medical University, Harbin, PR China.
PLoS One. 2015 Sep 1;10(9):e0134125. doi: 10.1371/journal.pone.0134125. eCollection 2015.
This study aimed to develop a set of indicators that could be used to measure and monitor the self-management performance for chronic hepatitis B (CHB) patients on antiviral therapy in China.
A two-round Delphi study via e-mail correspondence was conducted, with a group of 30 Chinese experts. The Delphi questionnaire consisted of 53 indicators identified from a literature review. Experts rated and scored the importance of indicators on a five-point Likert scale. Consensus was considered to be reached if a median score in the top tertile (4-5) and ≥ 80% of panel ratings in the top tertile (4-5) after Round 2. The included indicators were validated with a group of 106 CHB patients.
The response rates for the first and second rounds were 90.9% (n=30) and 86.7% (n=26), respectively. Three new indicators were suggested in the first round. 55 indicators were included in the second round after modified. 45 (81.8%) indicators achieved on the level of consensus, all of which had an inter-quartile range of 1 or below. The final set included 4 domains and 45 indicators which were well accepted and understandable by CHB patients.
This Delphi study produced a set of 45 self-management indicators for CHB patients on antiviral therapy in China. These indicators could be used to measure and monitor the patients' self-management performance, with the goal of improving the quality of life in this population.
本研究旨在制定一套可用于衡量和监测中国慢性乙型肝炎（CHB）抗病毒治疗患者自我管理绩效的指标。
通过电子邮件通信对30名中国专家进行了两轮德尔菲研究。德尔菲问卷由从文献综述中确定的53项指标组成。专家们采用五点李克特量表对指标的重要性进行评分。如果第二轮后三分位数顶端的中位数得分在4 - 5分且三分位数顶端的专家评分≥80%，则认为达成共识。纳入的指标在106名CHB患者群体中进行了验证。
第一轮和第二轮的回复率分别为90.9%（n = 30）和86.7%（n = 26）。第一轮提出了3项新指标。修改后第二轮纳入了55项指标。45项（81.8%）指标达成了共识水平，所有这些指标的四分位间距为1或以下。最终的指标集包括4个领域和45项指标，CHB患者对其接受度高且易于理解。
这项德尔菲研究为中国接受抗病毒治疗的CHB患者制定了一套45项自我管理指标。这些指标可用于衡量和监测患者的自我管理绩效，目标是提高该人群的生活质量。
