Giuliani Enrico, Bianchi Anna, Marcuzzi Augusto, Landi Antonio, Barbieri Alberto
Policlinico Teaching Hospital, University of Modena and Reggio Emilia, Modena, Italy.
Acta Ortop Bras. 2015 Jul-Aug;23(4):188-91. doi: 10.1590/1413-78522015230400736.
To evaluate the effect of pre-operative administration of ibuprofen on post-operative pain control vs. early post-operative administration for hand surgery procedures performed under local anaesthesia in ambulatory care.
Candidates to trigger finger release by De Quervain tenosynovitis and carpal tunnel operation under local anesthesia were enrolled in the study. Group A received 400 mg ibuprofen before the operation and placebo after the procedure; group B received placebo before the operation and ibuprofen 400 mg at the end of the procedure; both groups received ibuprofen 400 mg every 6h thereafter. Visual analogue scale (VAS) was measured at fixed times before and every 6h after surgery, for a total follow-up of 18h.
Groups were similar according to age, gender and type of surgery. Median VAS values did not produce any statistical significance, while there was a statistically significant difference on pre-operative and early post-operative VAS values between groups (A -8.53 mm vs. B 3.36 mm, p=0.0085).
Average pain levels were well controlled by local anesthesia and post-operative ibuprofen analgesia. Pre-operative ibuprofen administration can contribute to improve early pain management. Level of Evidence II, Therapeutic Studies.
评估术前给予布洛芬与术后早期给予布洛芬对门诊局部麻醉下进行的手部手术术后疼痛控制的效果。
纳入拟行局部麻醉下扳机指松解术及腕管手术的患者。A组术前给予400mg布洛芬，术后给予安慰剂；B组术前给予安慰剂，手术结束时给予400mg布洛芬；两组此后均每6小时给予400mg布洛芬。在术前固定时间及术后每6小时测量视觉模拟评分（VAS），共随访18小时。
两组在年龄、性别及手术类型方面相似。VAS中位数无统计学差异，但两组术前及术后早期VAS值有统计学差异（A组-8.53mm vs. B组3.36mm，p = 0.0085）。
局部麻醉及术后布洛芬镇痛可良好控制平均疼痛水平。术前给予布洛芬有助于改善早期疼痛管理。证据等级II，治疗性研究。
