Ko Yeong-Mu, Myung Sung-Woon, Kook Joong-Ki, Jung Sang-Chul, Kim Byung-Hoon
J Nanosci Nanotechnol. 2015 Jan;15(1):463-6. doi: 10.1166/jnn.2015.8371.
Antibacterial activity of oral pathogens such as Streptococcus mutans, Streptococcus sobrinus when silver ion immobilized on commercially pure (CP) titanium (Ti) surface was investigated in this study. Plasma-polymerized acrylic acid to have carboxyl group was deposited on CP-Ti surface and then ion-exchanged with Ag+ ions in 0.1 N AgNO3. In anti-adherent experiment, antibacterial activity was tested using broth culture methods. The biofilm formation assay was performed using semi-defined biofilm medium with sucrose. The silver coated CP-Ti completely inhibited the growth of S. mutans and S. sobrinus. In addition, the biofilm formation was significantly inhibited in silver-coated CP-Ti group.
本研究调查了银离子固定在商业纯钛(CP-Ti)表面时,对变形链球菌、远缘链球菌等口腔病原菌的抗菌活性。将具有羧基的等离子体聚合丙烯酸沉积在CP-Ti表面,然后在0.1N硝酸银中与银离子进行离子交换。在抗黏附实验中,采用肉汤培养法测试抗菌活性。使用含蔗糖的半限定生物膜培养基进行生物膜形成试验。涂银的CP-Ti完全抑制了变形链球菌和远缘链球菌的生长。此外,涂银CP-Ti组的生物膜形成受到显著抑制。