Lee Do-Jin, Kim Byung Hoon, Kim Sun-Jae, Kim Jung-Sik, Lee Heon, Jung Sang-Chul
J Nanosci Nanotechnol. 2015 Jan;15(1):680-3. doi: 10.1166/jnn.2015.8377.
An MDEL/TiO2 photo-catalyst hybrid system was applied, for the first time, for the production of low molecular weight heparin. The molecular weight of produed heparin decreased with increasing microwave intensity and treatment time. The abscission of the chemical bonds between the constituents of heparin by photo-catalytic reaction did not alter the characteristics of heparin. Formation of by-products due to side reaction was not observed. It is suggested that heparin was depolymerized by active oxygen radicals produced during the MDEL/TiO2 photo-chemical reaction.
首次将MDEL/TiO₂光催化剂混合系统应用于低分子量肝素的生产。所生产肝素的分子量随着微波强度和处理时间的增加而降低。光催化反应使肝素成分之间的化学键断裂，但并未改变肝素的特性。未观察到因副反应产生副产物的情况。据推测，肝素是被MDEL/TiO₂光化学反应过程中产生的活性氧自由基解聚的。
