特发性甲状旁腺功能减退症患者中γ-氨基丁酸能功能障碍与认知衰退之间的潜在联系

The Possible Link between GABAergic Dysfunction and Cognitive Decline in a Patient with Idiopathic Hypoparathyroidism.

作者信息

Terada Tatsuhiro, Kakimoto Akihiro, Yoshikawa Etsuji, Kono Satoshi, Bunai Tomoyasu, Hosoi Yasushi, Sakao-Suzuki Makiko, Konishi Takashi, Miyajima Hiroaki, Ouchi Yasuomi

机构信息

Department of Biofunctional Imaging, Medical Photonics Research Center, Hamamatsu University School of Medicine, Japan.

出版信息

Intern Med. 2015;54(17):2245-50. doi: 10.2169/internalmedicine.54.4295. Epub 2015 Sep 1.

DOI:10.2169/internalmedicine.54.4295

PMID:26328655

Abstract

Idiopathic hypoparathyroidism (IHP) is accompanied by cognitive impairment. We report the case of a 70-year-old IHP patient with cognitive disturbance. Brain computed tomography showed bilateral calcification in basal ganglia, thalamus, and cerebellum. Neuropsychological assessment revealed low scores for intelligence, memory, and perseverative errors. Brain positron emission tomography showed a significant reduction in [(18)F]-Fludeoxyglucose (FDG) uptake in bilateral frontal, left temporal and parietal cortices, along with a marked reduction in [(11)C]-flumazenil binding in left frontal, temporal, parietal, and bilateral cerebellum. These findings suggest cognitive impairment in IHP may be ascribed to GABAergic dysfunction, thus leading to, or coexisting with, cerebral hypometabolism.

摘要

特发性甲状旁腺功能减退症（IHP）伴有认知障碍。我们报告一例70岁患有认知障碍的IHP患者。脑部计算机断层扫描显示基底神经节、丘脑和小脑双侧钙化。神经心理学评估显示智力、记忆力和持续性错误得分较低。脑部正电子发射断层扫描显示双侧额叶、左侧颞叶和顶叶皮质的[（18）F] - 氟脱氧葡萄糖（FDG）摄取显著减少，同时左侧额叶、颞叶、顶叶和双侧小脑的[（11）C] - 氟马西尼结合显著减少。这些发现表明，IHP中的认知障碍可能归因于γ-氨基丁酸能功能障碍，从而导致脑代谢减退或与之并存。