衰老的心脏
The Aging Heart.
作者信息
Chiao Ying Ann, Rabinovitch Peter S
机构信息
Department of Pathology, University of Washington, Seattle, Washington 98195.
出版信息
Cold Spring Harb Perspect Med. 2015 Sep 1;5(9):a025148. doi: 10.1101/cshperspect.a025148.
Abstract
Aging results in progressive deteriorations in the structure and function of the heart and is a dominant risk factor for cardiovascular diseases, the leading cause of death in Western populations. Although the phenotypes of cardiac aging have been well characterized, the molecular mechanisms of cardiac aging are just beginning to be revealed. With the continuously growing elderly population, there is a great need for interventions in cardiac aging. This article will provide an overview of the phenotypic changes of cardiac aging, the molecular mechanisms underlying these changes, and will present some of the recent advances in the development of interventions to delay or reverse cardiac aging.
摘要
衰老导致心脏结构和功能逐渐衰退，是心血管疾病的主要风险因素，而心血管疾病是西方人群的主要死因。尽管心脏衰老的表型已得到充分表征，但心脏衰老的分子机制才刚刚开始被揭示。随着老年人口的不断增加，对心脏衰老干预措施的需求极为迫切。本文将概述心脏衰老的表型变化、这些变化背后的分子机制，并介绍在延缓或逆转心脏衰老干预措施开发方面的一些最新进展。
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