使用近红外光谱法（NIRS）通过基于小波相干分析揭示老年脑梗死患者的频率特异性功能连接。
Frequency-specific functional connectivity revealed by wavelet-based coherence analysis in elderly subjects with cerebral infarction using NIRS method.
作者信息
Tan Qitao, Zhang Ming, Wang Yi, Zhang Manyu, Wang Yan, Xin Qing, Wang Bitan, Li Zengyong
机构信息
Key Laboratory of High Efficiency and Clean Mechanical Manufacture, School of Mechanical Engineering, Shandong University, Jinan 250061, China.
Interdisciplinary Division of Biomedical Engineering, Faculty of Engineering, The Hong Kong Polytechnic University, Kowloon, Hong Kong Special Administrative Region, China.
出版信息
Med Phys. 2015 Sep;42(9):5391-403. doi: 10.1118/1.4928672.
PURPOSE
Resting-state functional connectivity in subjects with cerebral infarction (CI) was assessed using wavelet-based coherence analysis of near-infrared spectroscopy (NIRS) signals.
METHODS
Continuous recordings of NIRS signals were measured from the prefrontal cortex and sensorimotor cortical areas of 12 subjects with CI (CI group) and 16 healthy subjects (healthy group) during the resting state. The channels in these areas were divided into four connection types: homologous connectivity, frontoposterior connectivity, contralateral connectivity, and homolateral connectivity. Wavelet coherence (WCO) and wavelet phase coherence (WPCO) were calculated in six frequency intervals in each channel pair: I, 0.6-2 Hz; II, 0.145-0.6 Hz; III, 0.052-0.145 Hz; IV, 0.021-0.052 Hz; V, 0.0095-0.021 Hz; and VI, 0.005-0.0095 Hz.
RESULTS
WCO in the six frequency intervals was significant for all channels in the healthy group. By contrast, WCO in frequency intervals II-VI showed weakened connectivity in the CI group, especially in terms of frontoposterior connectivity. WCO was significantly lower in the CI group than in the healthy group in the following connectivities and frequency intervals: front-posterior, IV-VI (p < 0.05); homologous, III-V (p < 0.01); motor-contralateral, III-V (p < 0.05); and motor-homolateral, III-V (p < 0.05). WPCO in frequency intervals III (F = 5.032, p = 0.033) and IV (F = 11.95, p = 0.002) in frontoposterior connectivity, as well as in intervals III-V in homologous, motor-contralateral and motor-homolateral connectivities were significantly lower (p < 0.05) in the CI group than in the healthy group. However, WPCO in interval I showed significantly higher levels in motor-homolateral connectivity in the CI group than in the healthy group (F = 4.241, p = 0.049).
CONCLUSIONS
The authors' results suggest that CI causes a frequency-specific disruption in resting-state connectivity. This may be useful for assessing the effectiveness of functional recovery after CI.
目的
采用基于小波相干分析的近红外光谱（NIRS）信号评估脑梗死（CI）患者的静息态功能连接性。
方法
在静息状态下，对12例CI患者（CI组）和16例健康受试者（健康组）的前额叶皮质和感觉运动皮质区域进行NIRS信号的连续记录。这些区域的通道被分为四种连接类型：同源连接、前后连接、对侧连接和同侧连接。在每个通道对的六个频率区间计算小波相干（WCO）和小波相位相干（WPCO）：I，0.6 - 2Hz；II，0.145 - 0.6Hz；III，0.052 - 0.145Hz；IV，0.021 - 0.052Hz；V，0.0095 - 0.021Hz；VI，0.005 - 0.0095Hz。
结果
健康组所有通道在六个频率区间的WCO均显著。相比之下，CI组在频率区间II - VI的WCO显示连接性减弱，尤其是在前后连接方面。CI组在以下连接性和频率区间的WCO显著低于健康组：前后连接，IV - VI（p < 0.05）；同源连接，III - V（p < 0.01）；运动对侧连接，III - V（p < 0.05）；运动同侧连接，III - V（p < 0.05）。CI组在前后连接的频率区间III（F = 5.032，p = 0.033）和IV（F = 11.95，p = 0.002）以及同源、运动对侧和运动同侧连接的III - V区间的WPCO显著低于健康组（p < 0.05）。然而，CI组运动同侧连接在区间I的WPCO显著高于健康组（F = 4.241，p = 0.049）。
结论
作者的结果表明，CI导致静息态连接性出现频率特异性破坏。这可能有助于评估CI后功能恢复的有效性。
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