Karine Francine Docx Martine, Vandenberghe Philippe, Govaert Paul
a Department of Paediatrics, Chronic Paediatric Diseases , Queen Paola Children's Hospital , Antwerp , Belgium.
b Department of Paediatric Cardiology , Queen Paola Children's Hospital , Antwerp , Belgium.
Acta Clin Belg. 2016 Apr;71(2):117-8. doi: 10.1179/2295333715Y.0000000067. Epub 2016 Feb 8.
A 12-year-old African girl presented with multiple, sharply bordered hyperpigmented patches predominantly on the dorsal, tip and lateral aspects of the tongue since 1 year (Figs 1 and 2). On clinical examination, we found an obese adolescent girl with a BMI: 26.5 kg/m(2) ( > P97) with acanthosis nigricans of the neck. No medications were taken. Vitamin B12, liver tests and kidney function were normal. There was a decreased serum iron, 25OH vitamin D and zinc. Hyperinsulinism and heterozygosity for HbS (32%) were detected. Menarche: 12 years. No other family members were known with this anomaly.
一名12岁非洲女孩自1年前起舌背、舌尖及舌外侧出现多个边界清晰的色素沉着斑（图1和图2）。临床检查发现，这是一名肥胖青少年女性，体重指数（BMI）为26.5kg/m²（>P97），颈部有黑棘皮病。未服用任何药物。维生素B12、肝功能及肾功能正常。血清铁、25羟维生素D及锌水平降低。检测到高胰岛素血症及HbS杂合子（32%）。月经初潮年龄为12岁。无其他家庭成员有此异常情况。
