Provini Federica, Chiaro Giacomo
Department of Biomedical and Neuromotor Sciences, Bellaria Hospital, University of Bologna, Via Altura 3, Bologna 40139, Italy; IRCCS Institute of Neurological Sciences of Bologna, Bologna, Italy.
Department of Biomedical and Neuromotor Sciences, Bellaria Hospital, University of Bologna, Via Altura 3, Bologna 40139, Italy.
Sleep Med Clin. 2015 Sep;10(3):215-26, xi. doi: 10.1016/j.jsmc.2015.05.006. Epub 2015 Jun 13.
Neuroimaging studies are of crucial relevance in defining the pathophysiology of restless legs syndrome (RLS). MRI studies showed no structural brain lesions and confirmed a central iron deficiency. Structural and functional studies showed an involvement of the thalamus, sensorimotor cortical areas, and cerebellum in RLS and assessed neurotransmission abnormalities in the dopaminergic and opiate systems. Finally, glutamatergic hyperactivity has been proposed as a cause of disrupted and shortened sleep in RLS. Differences among the results of the studies make it difficult to draw any definitive conclusions, thus, suggesting the need for future research.
神经影像学研究对于明确不宁腿综合征（RLS）的病理生理学具有至关重要的意义。MRI研究未显示脑结构病变，并证实存在中枢性铁缺乏。结构和功能研究表明，丘脑、感觉运动皮层区域和小脑参与了RLS，并评估了多巴胺能和阿片系统中的神经传递异常。最后，谷氨酸能亢进被认为是RLS中睡眠中断和缩短的原因。研究结果之间的差异使得难以得出任何明确的结论，因此，表明需要未来的研究。
