不宁腿综合征/威利-埃克博姆病的病理生理学
Restless Leg Syndrome/Willis-Ekbom Disease Pathophysiology.
作者信息
Allen Richard P
机构信息
Department of Neurology, Johns Hopkins University, Asthma & Allergy Building, 1B76b, 5501 Hopkins Bayview Boulevard, Baltimore, MD 21224, USA.
出版信息
Sleep Med Clin. 2015 Sep;10(3):207-14, xi. doi: 10.1016/j.jsmc.2015.05.022. Epub 2015 Jul 15.
Abstract
Restless leg syndrome/Willis-Ekbom disease has brain iron deficiency that produces excessive dopamine and known genetic risks, some of which contribute to the brain iron deficiency. Dopamine treatments work temporarily but may eventually produce further postsynaptic down-regulation and worse restless leg syndrome. This article includes sections focused on pathophysiologic findings from each of these areas: genetics, cortical-spinal excitability, and iron and dopamine.
摘要
不宁腿综合征/威利-埃克博姆病存在脑铁缺乏，可产生过量多巴胺及已知的遗传风险，其中一些风险会导致脑铁缺乏。多巴胺治疗有暂时效果，但最终可能导致进一步的突触后下调及更严重的不宁腿综合征。本文包含分别聚焦于这些领域（遗传学、皮质-脊髓兴奋性、铁与多巴胺）病理生理发现的章节。
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