Geier Johannes, Schnuch Axel, Lessmann Holger, Uter Wolfgang
Information Network of Departments of Dermatology, Georg-August University, 37075, Göttingen, Germany.
Department of Medical Informatics, Biometry and Epidemiology, University of Erlangen/Nürnberg, 91054, Erlangen, Germany.
Contact Dermatitis. 2015 Nov;73(5):296-304. doi: 10.1111/cod.12468. Epub 2015 Aug 28.
Fragrance mix I (FM I) and its single constituents contain 5% and 1% sorbitan sesquioleate (SSO), respectively. SSO is a rare sensitizer and a potential irritant.
To determine whether the outcome of the FM I breakdown test is affected by positive patch test reactivity to SSO.
A retrospective analysis of data from the Information Network of Departments of Dermatology, 1998-2013, was performed.
The full FM I breakdown test including SSO was tested in 2952 patients. Of these, 154 (5.2%) had a positive patch test reaction to SSO 20% pet. and 2709 (91.8%) had a negative patch test reaction. Positive reactions to one or more of the single fragrances contained in the mix were significantly more common (82.5% versus 57.3%) in SSO-positive patients, who also had more multiple reactions than FM I-positive patients with negative SSO reactions (61.5% versus 21.3% patients with reactions to two or more fragrances).
Our results indicate that reactivity to SSO markedly affects the outcome of patch testing with FM I and its single constituents. SSO must be an obligatory part of the full FM I breakdown test, and should ideally be included in the baseline series.
香料混合物I（FM I）及其单一成分分别含有5%和1%的脱水山梨醇倍半油酸酯（SSO）。SSO是一种罕见的致敏剂和潜在的刺激物。
确定FM I分解试验的结果是否受对SSO斑贴试验阳性反应性的影响。
对1998 - 2013年皮肤科部门信息网络的数据进行回顾性分析。
对2952例患者进行了包括SSO在内的完整FM I分解试验。其中，154例（5.2%）对20%凡士林的SSO斑贴试验呈阳性反应，2709例（91.8%）斑贴试验呈阴性反应。在SSO阳性患者中，对混合物中一种或多种单一香料呈阳性反应的情况明显更为常见（82.5%对57.3%），且与SSO反应阴性的FM I阳性患者相比，SSO阳性患者出现多种反应的情况更多（对两种或更多香料有反应的患者分别为61.5%对21.3%）。
我们的结果表明，对SSO的反应性显著影响FM I及其单一成分的斑贴试验结果。SSO必须是完整FM I分解试验的必要组成部分，理想情况下应包含在基础系列中。
