Frosch P J, Pilz B, Burrows D, Camarasa J G, Lachapelle J M, Lahti A, Menné T, Wilkinson J D
Department of Dermatology, Städtische Kliniken Dortmund, Germany.
Contact Dermatitis. 1995 May;32(5):266-72. doi: 10.1111/j.1600-0536.1995.tb00779.x.
In a multicentre study, the value of adding sorbitan sesquioleate (SSO) to the constituents of the 8% fragrance mix (FM) was investigated. In 7 centres, 709 consecutive patients were tested with 2 types of FM from different sources, its 8 constituents with 1% SSO, its 8 constituents without SSO, and 20% SSO. 5 patients (0.71%) reacted to the emulsifier SSO itself, read as definitely allergic on day 3/4. 53 patients reacted to either one of the mixes with an allergic type of reaction. When tested with the constituents without SSO, 41.5% showed an allergic reaction versus 54.7% with SSO. If both types of reactions were considered (allergic and irritant) 38.3% of 73 patients showed a positive "breakdown" result without SSO, versus 54.8% with SSO. The differences were statistically significant. Reactivity to FM constituents was changed in a specific pattern by addition of SSO--irritant reactions increased, particularly for cinnamic alcohol, eugenol, geraniol, oak moss and hydroxycitronellal, whereas others showed only a slight change. Allergic reactions were also increased by SSO, but the rank order of the top 3 sensitizers (isoeugenol, oak moss and eugenol) did not change. Cinnamic alcohol was the only constituent with decreased reactivity after addition of SSO. A positive history of fragrance sensitivity (HFS) was clearly associated with a positive allergic reaction to either the mix or 1 of its constituents (51% versus 28.6% with a negative HFS). Irritant reactions were linked to a negative HFS in a high proportion (64.3%).(ABSTRACT TRUNCATED AT 250 WORDS)
在一项多中心研究中，调查了在8%香料混合物（FM）成分中添加脱水山梨醇倍半油酸酯（SSO）的价值。在7个中心，709名连续患者用来自不同来源的2种FM、其含1% SSO的8种成分、其不含SSO的8种成分以及20% SSO进行了测试。5名患者（0.71%）对乳化剂SSO本身有反应，在第3/4天判定为明确过敏。53名患者对其中一种混合物有过敏型反应。在对不含SSO的成分进行测试时，41.5%出现过敏反应，而含SSO时为54.7%。如果考虑两种反应类型（过敏和刺激），73名患者中38.3%在不含SSO时显示出阳性“分解”结果，含SSO时为54.8%。差异具有统计学意义。添加SSO后，对FM成分的反应性以特定模式发生变化——刺激反应增加，尤其是肉桂醇、丁香酚、香叶醇、橡苔和羟基香茅醛，而其他成分仅略有变化。SSO也增加了过敏反应，但前3种致敏剂（异丁香酚、橡苔和丁香酚）的排名顺序未改变。肉桂醇是添加SSO后反应性降低的唯一成分。香料敏感性阳性病史（HFS）与对混合物或其一种成分的阳性过敏反应明显相关（51%对HFS阴性时的28.6%）。刺激反应在很大比例上与HFS阴性相关（64.3%）。（摘要截断于250字）
