纳米颗粒作为新一代潜在的广谱抗菌剂。
Nanoparticles as potential new generation broad spectrum antimicrobial agents.
作者信息
Yah Clarence S, Simate Geoffrey S
机构信息
Department of Biochemistry and Microbiology, Nelson Mandela Metropolitan University, Port Elizabeth, South Africa.
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, E7146, 615 N. Wolfe Street, Baltimore, 21205, , MD, USA.
出版信息
Daru. 2015 Sep 2;23:43. doi: 10.1186/s40199-015-0125-6.
The rapid emergence of antimicrobial resistant strains to conventional antimicrobial agents has complicated and prolonged infection treatment and increased mortality risk globally. Furthermore, some of the conventional antimicrobial agents are unable to cross certain cell membranes thus, restricting treatment of intracellular pathogens. Therefore, the disease-causing-organisms tend to persist in these cells. However, the emergence of nanoparticle (NP) technology has come with the promising broad spectrum NP-antimicrobial agents due to their vast physiochemical and functionalization properties. In fact, NP-antimicrobial agents are able to unlock the restrictions experienced by conventional antimicrobial agents. This review discusses the status quo of NP-antimicrobial agents as potent broad spectrum antimicrobial agents, sterilization and wound healing agents, and sustained inhibitors of intracellular pathogens. Indeed, the perspective of developing potent NP-antimicrobial agents that carry multiple-functionality will revolutionize clinical medicine and play a significant role in alleviating disease burden.
传统抗菌药物耐药菌株的迅速出现使全球范围内的感染治疗变得复杂且延长了治疗时间，并增加了死亡风险。此外，一些传统抗菌药物无法穿过某些细胞膜，因此限制了细胞内病原体的治疗。所以，致病生物往往会在这些细胞中持续存在。然而，纳米颗粒（NP）技术的出现带来了前景广阔的广谱NP抗菌剂，这得益于它们丰富的物理化学和功能化特性。事实上，NP抗菌剂能够突破传统抗菌药物所面临的限制。本综述讨论了NP抗菌剂作为强效广谱抗菌剂、杀菌和伤口愈合剂以及细胞内病原体持续抑制剂的现状。的确，开发具有多种功能的强效NP抗菌剂的前景将彻底改变临床医学，并在减轻疾病负担方面发挥重要作用。
Zotero 插件