Yin Chen-Ting, Wen Zhi-Hong, Lan Yu-Hsuan, Chang Yu-Chia, Wu Yang-Chang, Sung Ping-Jyun
Graduate Institute of Marine Biology, National Dong Hwa University.
Chem Pharm Bull (Tokyo). 2015;63(9):752-6. doi: 10.1248/cpb.c15-00414.
Two new norcembranoids, sinumerolide A (1) and its epimer, 7E-sinumerolide A (2), were isolated from the ethyl acetate extract of the soft coral Sinularia numerosa. The structures of compounds 1 and 2 were established using spectroscopic methods. In the in vitro anti-inflammatory effect test, norcembranoids 1 and 2 were found to inhibit the accumulation of the pro-inflammatory inducible nitric oxide synthase protein of lipopolysaccharide-stimulated RAW264.7 macrophage cells significantly.
从软珊瑚中华指软珊瑚的乙酸乙酯提取物中分离出两种新的降碳环类化合物，中华指软珊瑚内酯A（1）及其差向异构体7E-中华指软珊瑚内酯A（2）。采用光谱方法确定了化合物1和2的结构。在体外抗炎效果试验中，发现降碳环类化合物1和2能显著抑制脂多糖刺激的RAW264.7巨噬细胞中促炎诱导型一氧化氮合酶蛋白的积累。
