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氧气——大脑恢复的一个限制因素。

Oxygen--a limiting factor for brain recovery.

作者信息

Hadanny Amir, Efrati Shai

机构信息

Sagol Center for Hyperbaric Medicine and Research, Assaf Harofeh Medical Center, Zerifin, 70300, Israel.

Sackler School of Medicine, Tel-Aviv University, Klachkin 25, Tel Aviv, 69978, Israel.

出版信息

Crit Care. 2015 Sep 1;19(1):307. doi: 10.1186/s13054-015-1034-2.

DOI:10.1186/s13054-015-1034-2
PMID:26329929
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4556415/
Abstract

Effective brain metabolism is highly dependent on a narrow therapeutic window of oxygen. In major insults to the brain (e.g., intracerebral hemorrhage), a slight decrease in oxygen supply, as occurs in a hypobaric environment at high altitude, has devastating effects on the injured brain tissue. Conversely, increasing brain oxygenation, by the use of hyperbaric oxygen therapy, can improve brain metabolism and its dependent regenerative processes.

摘要

有效的脑代谢高度依赖于狭窄的氧治疗窗。在对大脑的严重损伤(如脑出血)中,氧气供应的轻微减少,就像在高海拔的低压环境中发生的那样,会对受损的脑组织产生毁灭性影响。相反,通过使用高压氧疗法增加脑氧合,可以改善脑代谢及其相关的再生过程。

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本文引用的文献

1
Hyperbaric oxygen therapy ameliorates acute brain injury after porcine intracerebral hemorrhage at high altitude.高压氧疗法可改善高原地区猪脑出血后的急性脑损伤。
Crit Care. 2015 Jun 15;19(1):255. doi: 10.1186/s13054-015-0976-8.
2
Improvement of memory impairments in poststroke patients by hyperbaric oxygen therapy.高压氧疗法改善中风后患者的记忆障碍
Neuropsychology. 2015 Jul;29(4):610-21. doi: 10.1037/neu0000149. Epub 2014 Nov 10.
3
Reflections on the neurotherapeutic effects of hyperbaric oxygen.高压氧的神经治疗作用反思。
Expert Rev Neurother. 2014 Mar;14(3):233-6. doi: 10.1586/14737175.2014.884928. Epub 2014 Jan 29.
4
Hyperbaric oxygen therapy can improve post concussion syndrome years after mild traumatic brain injury - randomized prospective trial.高压氧治疗可改善轻度创伤性脑损伤多年后的脑震荡后综合征 - 随机前瞻性试验。
PLoS One. 2013 Nov 15;8(11):e79995. doi: 10.1371/journal.pone.0079995. eCollection 2013.
5
Hyperbaric oxygen induces late neuroplasticity in post stroke patients--randomized, prospective trial.高压氧治疗脑卒中后患者的迟发性神经可塑性:随机、前瞻性试验。
PLoS One. 2013;8(1):e53716. doi: 10.1371/journal.pone.0053716. Epub 2013 Jan 15.
6
Brain oxygenation and energy metabolism: part I-biological function and pathophysiology.脑氧合与能量代谢:第一部分——生物学功能与病理生理学
Neurosurgery. 2002 Aug;51(2):289-301; discussion 302.