Fatima P, Hossain M M, Rahman D, Rahman M W, Mugni C R, Sumon G M, Hossain H B, Hossain H N
Professor Parveen Fatima, Professor of Infertility Unit, Department of Gynae & Obs., Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh.
Mymensingh Med J. 2015 Jul;24(3):537-41.
This cross sectional study was carried out in Center for Assisted Reproduction, Dhaka, and in the Department of Biochemistry, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh from July 2012 to December 2012. The study population was 71 consecutive male partners of infertile couple suffering from at least one year of infertility. Lead and Zinc level was measured in blood and semen in the male partner of infertile couple and compared with semen parameters. Serum zinc at different values did not show any statistically significant change in semen volume, total count of sperm and total motility of sperm. At serum zinc level 80-< 90 μg/dl blood lead and semen lead level was lowest 20.6 ± 8.60 μg/dl and 48.17 ± 51.33 μg/dl respectively and showed highest total count of sperm (54.00 ± 46.67 million/ml) but was not statistically significant. Rapid linear motility and normal sperm morphology was also highest at values 80-< 90 μg/dl and was 45.33 ± 26.62% and 36.67 ± 11.60% respectively and was statistically significant. At serum zinc level > 90 μg/dl semen lead level was significantly higher (120.73 ± 58.02 μg/dl) and showed statistically significant decrease in rapid linear motility and normal sperm morphology. Total count of sperm was lowest at blood zinc level of 70-< 80 μg/dl. Sperm morphology also showed statistically significant improvement at Serum zinc values of 80-< 90 μg/dl. The results suggest that Serum zinc level of values 80-< 90 μg/dl is the optimum level to have the best impact on semen parameter as well it is the critical level at which the semen lead level is lowest. Serum zinc levels higher as well as lower than values 80-< 90 μg/dl was associated with increased semen lead values and with negative impact on semen parameters.
这项横断面研究于2012年7月至2012年12月在达卡的辅助生殖中心以及孟加拉国达卡的班加班杜·谢赫·穆吉布医科大学生物化学系开展。研究对象为71名连续入选的不育夫妇的男性伴侣，他们患有至少一年的不育症。对不育夫妇男性伴侣的血液和精液中的铅和锌水平进行了测量，并与精液参数进行比较。不同血清锌值时，精液量、精子总数和精子总活力均未显示出任何统计学上的显著变化。血清锌水平在80 - < 90μg/dl时，血铅和精液铅水平最低，分别为20.6±8.60μg/dl和48.17±51.33μg/dl，精子总数最高（54.00±46.67百万/ml），但无统计学意义。快速直线运动精子和正常精子形态在80 - < 90μg/dl时也最高，分别为45.33±26.62%和36.67±11.60%，具有统计学意义。血清锌水平> 90μg/dl时，精液铅水平显著升高（120.73±58.02μg/dl），快速直线运动精子和正常精子形态有统计学意义的下降。精子总数在血锌水平70 - < 80μg/dl时最低。精子形态在血清锌值80 - < 90μg/dl时也有统计学意义的改善。结果表明，血清锌水平80 - < 90μg/dl是对精液参数影响最佳的最佳水平，也是精液铅水平最低的临界水平。血清锌水平高于或低于80 - < 90μg/dl均与精液铅值升高及精液参数的负面影响相关。
