慢性乙型肝炎中结缔组织生长因子（CTGF/CCN2）与肝纤维化的相关性
Correlation of Connective Tissue Growth Factor (CTGF/CCN2) with Hepatic Fibrosis in Chronic Hepatitis B.
作者信息
Ferdoushi S, Paul D, Ghosh C K, Sultana T, Joarder A I, Islam M S, Islam M S, Mahmuduzzaman M, Rahman Q, Ahmed A N
机构信息
Dr Sheuly Ferdoushi, Medical Officer, Department of Gastroenterology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh.
出版信息
Mymensingh Med J. 2015 Jul;24(3):558-63.
CTGF/CCN2 plays an important role in the formation and development of hepatic fibrosis. This study determined the correlation between serum CTGF/CCN2 and stages of hepatic fibrosis and explored the clinical value of serum CTGF/CCN2 in the assessment of hepatic fibrosis in chronic hepatitis B. This cross sectional study was done in department of Clinical Pathology, Bangabandhu Sheikh Mujib Medical University, Dhaka from March 2012 to February 2013. Serum CTGF was measured by using of a sandwich immunoassay technique. Forty (40) chronic hepatitis B patients were included in this study. The sensitivity of CTGF/CCN2 was 71.6%, specificity 67.5%. Spearman's rank correlation coefficient was 0.652 between serum CTGF/CCN2 and stages of hepatic fibrosis (p<0.001). The area under receiver-operating curve (ROC) was 0.750 for identification of hepatic fibrosis. This present data revealed that serum CTGF/CCN2 in chronic hepatitis B were strongly associated with stages of hepatic fibrosis. CTGF/CCN2 may useful diagnostic tool for assessing the hepatic fibrosis in chronic hepatitis B.
结缔组织生长因子/CCN2在肝纤维化的形成和发展过程中发挥着重要作用。本研究确定了血清结缔组织生长因子/CCN2与肝纤维化分期之间的相关性，并探讨了血清结缔组织生长因子/CCN2在评估慢性乙型肝炎肝纤维化中的临床价值。这项横断面研究于2012年3月至2013年2月在达卡的班加班杜·谢赫·穆吉布医科大学临床病理科进行。采用夹心免疫测定技术检测血清结缔组织生长因子。本研究纳入了40例慢性乙型肝炎患者。结缔组织生长因子/CCN2的敏感性为71.6%，特异性为67.5%。血清结缔组织生长因子/CCN2与肝纤维化分期之间的Spearman等级相关系数为0.652（p<0.001）。用于识别肝纤维化的受试者工作特征曲线（ROC）下面积为0.750。目前的数据显示，慢性乙型肝炎患者血清结缔组织生长因子/CCN2与肝纤维化分期密切相关。结缔组织生长因子/CCN2可能是评估慢性乙型肝炎肝纤维化的有用诊断工具。
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