Yang Jingjin, Wang Lijuan, Wang Ting, Chen Congcong, Han Lei, Ji Xiaoming, Wu Baiqun, Han Ruhui, Ni Chunhui
a Department of Occupational Medicine and Environmental Health , School of Public Health, Nanjing Medical University , Nanjing , China.
Inhal Toxicol. 2015;27(12):641-8. doi: 10.3109/08958378.2015.1080774. Epub 2015 Sep 2.
The matrix metalloproteinase-7 (MMP-7) and osteopontin (OPN) are both multifunctional proteins with roles in inflammation, cell proliferation, tissue remodeling and so on, implicated in the pathogenesis of numerous conditions including pulmonary fibrosis. In this study, we investigated the associations between the potential functional polymorphisms in MMP-7 and OPN and the risk of coal workers' pneumoconiosis (CWP) in a Chinese population.
Four polymorphisms (rs10502001 in MMP-7, rs1126772, rs11728697 and rs9138 in OPN) were genotyped and analyzed in a case-control study of 697 CWP and 694 control subjects.
Our results revealed that three single nucleotide polymorphisms (SNPs, MMP-7 rs10502001, OPN rs1126772 and OPN rs11728697) were associated with increased risk of CWP under a recessive model (adjusted odds ratio [OR]=1.80, 95% confidence interval [CI]=1.01-3.20, p=0.045 for MMP-7 rs10502001; adjusted OR=2.09, 95% CI=1.17-3.72, p=0.013 for OPN rs1126772; adjusted OR=2.48, 95% CI=1.37-4.51, p=0.003 for OPN rs11728697). Additionally, a combined effect was observed in a dose-dependent manner with increasing numbers of risk variant alleles (Ptrend=0.003). Furthermore, logistic regression analysis revealed no significant interaction between SNPs and smoking status on CWP risk.
Our results indicate that three functional SNPs (MMP-7 rs10502001, OPN rs11728697 and OPN rs1126772) are associated with an increased risk of CWP in a Chinese population.
基质金属蛋白酶-7（MMP-7）和骨桥蛋白（OPN）都是多功能蛋白，在炎症、细胞增殖、组织重塑等过程中发挥作用，与包括肺纤维化在内的多种疾病的发病机制有关。在本研究中，我们调查了中国人群中MMP-7和OPN潜在功能多态性与煤工尘肺（CWP）风险之间的关联。
在一项包含697例CWP患者和694例对照受试者的病例对照研究中，对4种多态性（MMP-7中的rs10502001、OPN中的rs1126772、rs11728697和rs9138）进行基因分型和分析。
我们的结果显示，在隐性模型下，3个单核苷酸多态性（SNP，MMP-7 rs10502001、OPN rs1126772和OPN rs11728697）与CWP风险增加相关（MMP-7 rs10502001的校正比值比[OR]=1.80，95%置信区间[CI]=1.01-3.20，p=0.045；OPN rs1126772的校正OR=2.09，95% CI=1.17-3.72，p=0.013；OPN rs11728697的校正OR=2.48，95% CI=1.37-4.51，p=0.003）。此外，随着风险变异等位基因数量增加，观察到剂量依赖性的联合效应（Ptrend=0.003）。此外，逻辑回归分析显示SNP与吸烟状态之间在CWP风险上无显著交互作用。
我们的结果表明，3个功能性SNP（MMP-7 rs10502001、OPN rs11728697和OPN rs1126772）与中国人群中CWP风险增加相关。
