Zhao Yingming, Garcia Benjamin A
Ben May Department for Cancer Research, The University of Chicago, Chicago, Illinois 60637.
Epigenetics Program, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104.
Cold Spring Harb Perspect Biol. 2015 Sep 1;7(9):a025064. doi: 10.1101/cshperspect.a025064.
Modern techniques in molecular biology, genomics, and mass spectrometry-based proteomics have identified a large number of novel histone posttranslational modifications (PTMs), many of whose functions are still under intense investigation. Here, we catalog histone PTMs under two classes: first, those whose functions have been fairly well studied and, second, those PTMs that have been more recently identified but whose functions remain unclear. We hope that this will be a useful resource for researchers from all biological or technical backgrounds, aiding in their chromatin and epigenetic pursuits.
分子生物学、基因组学以及基于质谱的蛋白质组学中的现代技术已鉴定出大量新型组蛋白翻译后修饰（PTM），其中许多修饰的功能仍在深入研究中。在此，我们将组蛋白PTM分为两类：第一类是功能已得到相当充分研究的修饰；第二类是最近才鉴定出但功能仍不清楚的PTM。我们希望这将成为所有生物学或技术背景研究人员的有用资源，有助于他们在染色质和表观遗传学方面的探索。
