Lin Pei-Hsuan, Wang Cheng-Ping, Lou Pei-Jen, Ko Jeng-Yuh, Hsiao Tzu-Yu, Chen Tseng-Cheng
Department of Otolaryngology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
Department of Otolaryngology, National Taiwan University Hospital Yun-Lin Branch, Yun-Lin, Taiwan.
Head Neck. 2016 Apr;38 Suppl 1:E1137-43. doi: 10.1002/hed.24174. Epub 2015 Sep 2.
The purposes of this study were to identify an index of symptoms and signs of swallowing disorders that indicate the occurrence of local recurrence or second primary malignancy and to evaluate the application of transnasal esophagoscopy in patients treated for head and neck squamous cell carcinoma (HNSCC).
Patients treated for HNSCC with swallowing disorders who received transnasal esophagoscopy examinations between January 2010 and June 2014 were included in this study. Local recurrence and second primary malignancy were pathologically diagnosed.
In total, 136 patients were examined and one-third of them had local recurrence or second primary malignancy. Thirty-two patients had local recurrence and 14 patients had second primary malignancy. Common swallowing disorders and objective transnasal esophagoscopy findings were similar between the patients with and without local recurrence or second primary malignancy.
No definite index of symptoms and signs was an indicator of local recurrence or second primary malignancy in the patients treated for HNSCC. Routine transnasal esophagoscopy examination of patients treated for HNSCC with swallowing disorders is strongly recommended. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1137-E1143, 2016.
本研究的目的是确定吞咽障碍的症状和体征指标，以提示局部复发或第二原发性恶性肿瘤的发生，并评估经鼻食管镜检查在头颈部鳞状细胞癌（HNSCC）患者治疗中的应用。
本研究纳入了2010年1月至2014年6月期间接受经鼻食管镜检查且患有吞咽障碍的HNSCC患者。局部复发和第二原发性恶性肿瘤通过病理诊断。
总共检查了136例患者，其中三分之一患有局部复发或第二原发性恶性肿瘤。32例患者有局部复发，14例患者有第二原发性恶性肿瘤。有和没有局部复发或第二原发性恶性肿瘤的患者之间，常见的吞咽障碍和经鼻食管镜客观检查结果相似。
在接受治疗的HNSCC患者中，没有明确的症状和体征指标可提示局部复发或第二原发性恶性肿瘤。强烈建议对患有吞咽障碍的HNSCC患者进行常规经鼻食管镜检查。©2015威利期刊公司。《头颈》38：E1137 - E1143，2016年。
