Blader Ira J, Coleman Bradley I, Chen Chun-Ti, Gubbels Marc-Jan
Department of Microbiology and Immunology, University at Buffalo, Buffalo, New York 14127; email:
Department of Biology, Boston College, Chestnut Hill, Massachusetts 02467; email:
Annu Rev Microbiol. 2015;69:463-85. doi: 10.1146/annurev-micro-091014-104100. Epub 2015 Aug 28.
Toxoplasmosis is the clinical and pathological consequence of acute infection with the obligate intracellular apicomplexan parasite Toxoplasma gondii. Symptoms result from tissue destruction that accompanies lytic parasite growth. This review updates current understanding of the host cell invasion, parasite replication, and eventual egress that constitute the lytic cycle, as well as the ways T. gondii manipulates host cells to ensure its survival. Since the publication of a previous iteration of this review 15 years ago, important advances have been made in our molecular understanding of parasite growth and mechanisms of host cell egress, and knowledge of the parasite's manipulation of the host has rapidly progressed. Here we cover molecular advances and current conceptual frameworks that include each of these topics, with an eye to what may be known 15 years from now.
弓形虫病是由专性细胞内顶复门寄生虫刚地弓形虫急性感染所导致的临床和病理后果。症状源于伴随溶解性寄生虫生长的组织破坏。本综述更新了对构成溶解性周期的宿主细胞入侵、寄生虫复制以及最终逸出的当前认识，以及刚地弓形虫操纵宿主细胞以确保其存活的方式。自15年前本综述的上一版发表以来，我们在对寄生虫生长的分子理解和宿主细胞逸出机制方面取得了重要进展，并且对寄生虫操纵宿主的了解也迅速发展。在这里，我们涵盖了包括上述每个主题的分子进展和当前概念框架，着眼于从现在起15年后可能已知的内容。
