Saurí Josep, Parella Teodor, Williamson R Thomas, Martin Gary E
Process and Analytical Chemistry, NMR Structure Elucidation, Merck Research Laboratories, Rahway, NJ, 07065, USA.
Servei de Ressonància Magnètica Nuclear, Universitat Autònoma de Barcelona, 08193, Bellaterra (Barcelona), Catalonia, Spain.
Magn Reson Chem. 2017 Mar;55(3):191-197. doi: 10.1002/mrc.4322. Epub 2015 Aug 31.
Homonuclear C- C couplings at natural abundance can be measured using the J-modulated Adequate DoublE QUAntumTransfer Experiment (ADEQUATE) experiment. To somewhat ameliorate F digitization requirements, a scaling factor was incorporated into the original pulse sequence. Non-uniform sampling provides an obvious avenue to further facilitate the acquisition of J and J homonuclear coupling constant data. We introduce homonuclear decoupling (HD) analogous to that described for the 1,1-HD-ADEQUATE and 1,n-HD-ADEQUATE experiments and evaluate the combination of non-uniform sampling and HD on the acquisition of both J and J homonuclear C- C coupling constants using ibuprofen as a model compound. Copyright © 2015 John Wiley & Sons, Ltd.
利用J调制的充分双量子转移实验（ADEQUATE）可以测量自然丰度下的同核C-C耦合。为了在一定程度上改善对F数字化的要求，在原始脉冲序列中加入了一个比例因子。非均匀采样为进一步促进J和J同核耦合常数数据的采集提供了一条明显的途径。我们引入了类似于1,1-HD-ADEQUATE和1,n-HD-ADEQUATE实验中所描述的同核去耦（HD），并以布洛芬为模型化合物，评估非均匀采样和HD相结合对J和J同核C-C耦合常数采集的影响。版权所有© 2015约翰·威利父子有限公司。
