Low-cost oral delivery of protein drugs bioencapsulated in plant cells.
作者信息
Kwon Kwang-Chul, Daniell Henry
机构信息
Department of Biochemistry, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.
出版信息
Plant Biotechnol J. 2015 Oct;13(8):1017-22. doi: 10.1111/pbi.12462. Epub 2015 Sep 3.
Abstract
摘要
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本文引用的文献
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The Engineered Chloroplast Genome Just Got Smarter.人工合成的叶绿体基因组变得更智能了。
Trends Plant Sci. 2015 Oct;20(10):622-640. doi: 10.1016/j.tplants.2015.07.004.
2
Low cost industrial production of coagulation factor IX bioencapsulated in lettuce cells for oral tolerance induction in hemophilia B.低成本工业化生产封装在生菜细胞中的凝血因子IX，用于诱导B型血友病的口服耐受性。
Biomaterials. 2015 Nov;70:84-93. doi: 10.1016/j.biomaterials.2015.08.004. Epub 2015 Aug 5.
3
Oral delivery of Acid Alpha Glucosidase epitopes expressed in plant chloroplasts suppresses antibody formation in treatment of Pompe mice.经植物叶绿体表达的酸性α-葡萄糖苷酶表位的口服给药可抑制庞贝病小鼠的抗体形成，从而达到治疗效果。
Plant Biotechnol J. 2015 Oct;13(8):1023-32. doi: 10.1111/pbi.12413. Epub 2015 Jun 5.
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Biopharmaceutical benchmarks 2014.2014年生物制药基准
Nat Biotechnol. 2014 Oct;32(10):992-1000. doi: 10.1038/nbt.3040.
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Mol Ther. 2014 Dec;22(12):2069-2082. doi: 10.1038/mt.2014.179. Epub 2014 Sep 17.
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Oral delivery of Angiotensin-converting enzyme 2 and Angiotensin-(1-7) bioencapsulated in plant cells attenuates pulmonary hypertension.口服封装于植物细胞中的血管紧张素转换酶2和血管紧张素-（1-7）可减轻肺动脉高压。
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Suppression of inhibitor formation against FVIII in a murine model of hemophilia A by oral delivery of antigens bioencapsulated in plant cells.通过口服植物细胞生物包封的抗原抑制A型血友病小鼠模型中针对FVIII的抑制剂形成。
Blood. 2014 Sep 4;124(10):1659-68. doi: 10.1182/blood-2013-10-528737. Epub 2014 May 13.
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A fusion protein derived from plants holds promising potential as a new oral therapy for type 2 diabetes.一种源自植物的融合蛋白有望成为 2 型糖尿病的新型口服疗法。
Plant Biotechnol J. 2014 May;12(4):425-35. doi: 10.1111/pbi.12149. Epub 2013 Dec 30.
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Oral delivery of bioencapsulated proteins across blood-brain and blood-retinal barriers.经口递送至血脑和血视网膜屏障内的生物包封蛋白。
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Oral delivery of bioencapsulated exendin-4 expressed in chloroplasts lowers blood glucose level in mice and stimulates insulin secretion in beta-TC6 cells.叶绿体表达的生物囊封 exendin-4 的口服给药可降低小鼠的血糖水平，并刺激 beta-TC6 细胞中的胰岛素分泌。
Plant Biotechnol J. 2013 Jan;11(1):77-86. doi: 10.1111/pbi.12008. Epub 2012 Oct 18.
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