Hakansson C H, Albertsson M, Palmegren M
Department of Oncology, University Hospital, Lund, Sweden.
Scanning Microsc. 1989 Dec;3(4):1169-76.
The mucosa of rabbit esophagus was irradiated with single doses of 10 and 20 Gy respectively. Specimens were taken for scanning electron microscopy (SEM), and light microscopy investigations. Examinations were made 1-14 days after 10 Gy and 1-17 days after 20 Gy. Irradiation resulted in edema during the first days. The thickness of the epithelium was at its lowest value around day 5 after the administration of 10 Gy, and on days eight to ten after the administration of 20 Gy. Damage of the epithelium surface, as scored on SEM micrographs, was most pronounced on days eight to eleven after irradiation, showing a clear dose dependency. The second week after irradiation repair was seen concluding in an overshoot of the mucosal height. The amount of bacteria on the surface increased during the period of edema, and decreased when the damage was most pronounced.
分别用10 Gy和20 Gy的单剂量照射兔食管黏膜。取标本进行扫描电子显微镜（SEM）和光学显微镜检查。在10 Gy照射后1 - 14天以及20 Gy照射后1 - 17天进行检查。照射在最初几天导致水肿。给予10 Gy后约第5天上皮厚度达到最低值，给予20 Gy后第8至10天上皮厚度达到最低值。根据SEM显微照片评分，上皮表面损伤在照射后第8至11天最为明显，呈现明显的剂量依赖性。照射后第二周可见修复，最终黏膜高度出现超调。水肿期间表面细菌数量增加，在损伤最明显时减少。
