Albertsson M, Cwikiel M, Håkansson C H, Palmegren M
Department of Oncology, University Hospital, Lund, Sweden.
Scanning Microsc. 1992 Dec;6(4):1023-33; discussion 1033-4.
The rabbit esophageal mucosa was irradiated with daily fractions of 2 Gy up to an accumulated dose of 20 Gy (total dose 2, 6, 10. 16 or 20 Gy). Fifteen to forty-five minutes before the start of each irradiation 0.3 mg Cis-dichlorodiammineplatinum (cis-DDP, cisplatinum) was given by intraperitoneal injection to each rabbit. Examinations were carried out 1-10 days after each fractionation schedule, when specimens were taken for morphological investigations. Scanning electron microscope (SEM) examination showed a gradual development of damage with cell loss and structural disarrangement of the microridges and whorls on the surface. However, with further treatment the esophageal mucosa exposed to cis-DDP and radiation normalized faster and more complete compared to the esophageal part exposed to cis-DDP alone. The difference may depend on an accelerated proliferation in the part of the trachea that is exposed to a combined treatment.
对兔食管黏膜进行照射，每日分次给予2 Gy，累积剂量达20 Gy（总剂量为2、6、10、16或20 Gy）。在每次照射开始前15至45分钟，给每只兔腹腔注射0.3 mg顺二氯二氨铂（顺铂）。在每个分次照射方案后的1至10天进行检查，此时采集标本进行形态学研究。扫描电子显微镜（SEM）检查显示损伤逐渐发展，伴有细胞丢失以及表面微嵴和涡旋结构紊乱。然而，与仅接受顺铂治疗的食管部分相比，接受顺铂和放疗联合治疗的食管黏膜恢复正常的速度更快且更完全。这种差异可能取决于接受联合治疗的气管部分增殖加速。
