Ardigò M, Prow T, Agozzino M, Soyer P, Berardesca E
Istituto Dermatologico San Gallicano IRCCS, Rome, Italy -
G Ital Dermatol Venereol. 2015 Oct;150(5):565-73.
Reflectance confocal microscopy evaluation of inflammatory skin diseases represents a relatively new indication that, during the last 5 years, has shown an increasing interest with consequent progressive increment of publications in literature. The success of RCM in this filed of dermatology is directly related to the high needing of non-invasive techniques able to reduce the number of skin biopsies and support the clinical diagnosis and patient's management. RCM demonstrated to visualize microscopic descriptors of inflammatory and pigmentary skin conditions with good reproducibility between observer and high grade of correspondence with optical histology. Moreover, RCM has shown to provide sufficient data to support clinical diagnosis and differential diagnosis of inflammatory and pigmentary skin diseases. Recently, several works published in literature have opened the prospective to use RCM also for therapeutic follow-up in order to monitor the improvement of the microscopic parameters and help to prevent treatment side effects. In this review article we present some examples of RCM application in inflammatory and pigmentary diseases.
反射式共聚焦显微镜对炎症性皮肤病的评估是一个相对较新的应用领域，在过去5年里，该领域受到越来越多的关注，相关文献发表数量也随之逐渐增加。反射式共聚焦显微镜在皮肤科这一领域的成功，直接源于对能够减少皮肤活检数量、辅助临床诊断和患者管理的非侵入性技术的迫切需求。反射式共聚焦显微镜已被证明能够可视化炎症性和色素性皮肤病的微观特征，观察者之间具有良好的可重复性，并且与光学组织学高度吻合。此外，反射式共聚焦显微镜已显示出能够提供足够的数据来支持炎症性和色素性皮肤病的临床诊断和鉴别诊断。最近，文献中发表的几项研究为将反射式共聚焦显微镜用于治疗随访开辟了前景，以便监测微观参数的改善情况，并有助于预防治疗副作用。在这篇综述文章中，我们展示了反射式共聚焦显微镜在炎症性和色素性疾病中的一些应用实例。
