糖皮质激素在慢性鼻-鼻窦炎中的作用机制。
Mechanisms of Glucocorticoid Action in Chronic Rhinosinusitis.
机构信息
Department of Otorhinolaryngology-Head & Neck Surgery, College of Medicine, Korea University, Seoul, Korea.
出版信息
Allergy Asthma Immunol Res. 2015 Nov;7(6):534-7. doi: 10.4168/aair.2015.7.6.534. Epub 2015 May 20.
Abstract
The innate immune system and its complex interplay with the adaptive immune system are increasingly being recognized as important factors in the pathogenesis of chronic rhinosinusitis (CRS). Adaptive immune components, including resident and inflammatory cells, and their associated mediators, have been the subject of most research in CRS. For this reason, theories of CRS pathogenesis have involved the concept that inflammation, rather than infection, is the dominant etiologic factor in CRS. Therefore, glucocorticoids are increasingly used to treat CRS. This review will outline our current knowledge of action mode of glucocorticoids in CRS.
摘要
固有免疫系统及其与适应性免疫系统的复杂相互作用，日益被认为是慢性鼻-鼻窦炎（CRS）发病机制的重要因素。适应性免疫成分，包括常驻和炎性细胞及其相关介质，一直是 CRS 研究的主要对象。由于这个原因，CRS 发病机制的理论涉及到炎症而不是感染是 CRS 的主要病因因素的概念。因此，糖皮质激素越来越多地被用于治疗 CRS。这篇综述将概述我们目前对糖皮质激素在 CRS 中作用模式的认识。
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