Petrov D
Vutr Boles. 1989;28(6):21-5.
The combination of bronchial asthma and ischemic heart disease presents new qualitative problems related to the diagnosis and treatment, 476 patients with bronchial asthma above 48 years of age (mean age 56.9 years) were studied. In 294 of these patients (61.7%) ischemic heart disease was found as an accompanying disease. In 31 patients (6.15%) there were signs of past myocardial infarction. The ischemic heart diseases presented with typical clinical features in 33.33% of the patients only. In the remaining 66.67% the disease ran a silent course with-out pain. In the combination bronchial asthma and ischemic heart diseases the diagnostic criteria of the ECG in rest fall to 55%. Many pathogenic factors, facilitating and aggravating, change the clinical characteristic of the combined diseases. The combination leads to new therapeutic problems, since the therapeutic approaches to them are different and sometimes opposite. The active treatment of one of the disease may lead to iatrogenic deterioration of the other.
支气管哮喘与缺血性心脏病并存出现了与诊断和治疗相关的新的质性问题，对476例48岁以上（平均年龄56.9岁）的支气管哮喘患者进行了研究。其中294例患者（61.7%）被发现患有缺血性心脏病这一伴发疾病。31例患者（6.15%）有既往心肌梗死迹象。仅33.33%的患者缺血性心脏病表现出典型临床特征。其余66.67%的患者病情呈无症状性进展。在支气管哮喘与缺血性心脏病并存的情况下，静息心电图的诊断标准降至55%。许多促进和加重病情的致病因素改变了合并疾病的临床特征。这种并存导致了新的治疗问题，因为针对它们的治疗方法不同，有时甚至相反。积极治疗其中一种疾病可能导致另一种疾病医源性恶化。
