热应激诱导含有HSC70蛋白的细胞质颗粒形成。
Heat stress induces formation of cytoplasmic granules containing HSC70 protein.
作者信息
Ivanova A A, Velichko A K, Kantidze O L, Razin S V
机构信息
Institute of Gene Biology, Russian Academy of Sciences, ul. Vavilova 34/5, Moscow, 119334, Russia.
出版信息
Dokl Biochem Biophys. 2015;463:213-5. doi: 10.1134/S1607672915040043. Epub 2015 Sep 3.
Using indirect immunofluorescence, in this study we showed that the constitutive heat shock protein HSC70 forms granule-like structures in the cytoplasm of human cells several days after the exposure to heat stress. It was shown that this effect is not the result of HSC70 overexpression under heat stress and is not due to the formation of hyperthermia-induced translational stress granules in the cytoplasm.
在本研究中，我们通过间接免疫荧光法显示，在热应激暴露数天后，组成型热休克蛋白HSC70在人类细胞的细胞质中形成颗粒样结构。结果表明，这种效应不是热应激下HSC70过表达的结果，也不是由于细胞质中热诱导的翻译应激颗粒的形成。
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