Zhang T X, Wang Y F, Ciriello J
Department of Physiology, University of Western Ontario, London, Canada.
Am J Chin Med. 1989;17(3-4):211-9. doi: 10.1142/S0192415X89000309.
In this study, the effect of the herbal prescription Tian Ma Gou Teng Yen (TGY), which is traditionally used to treat certain diseases associated with elevated arterial pressure (AP), on the general development of hypertension was investigated in the spontaneously hypertensive rat (SHR). An aqueous extract of TGY was given orally (0.5 ml/100g body weight) to 5 week old SHR twice a day for six consecutive days followed by one day without herbal therapy. The herbal prescription was administered until the SHR were 16 weeks of age. Administration of TGY significantly altered the development and prevented hypertension in SHR. On the other hand, heart rate, body weight, food and water intake, and urine volume and electrolytes were not altered. These data suggest that the effect of TGY on AP was through an action of TGY on sympathetic vasomotor activity.
在本研究中，在自发性高血压大鼠（SHR）中研究了传统上用于治疗某些与动脉压（AP）升高相关疾病的中药天麻钩藤饮（TGY）对高血压总体发展的影响。将TGY水提取物以0.5 ml/100g体重口服给予5周龄的SHR，每天两次，连续六天，随后一天不进行草药治疗。该中药方剂持续给药至SHR 16周龄。给予TGY显著改变了SHR的高血压发展并预防了高血压。另一方面，心率、体重、食物和水摄入量以及尿量和电解质均未改变。这些数据表明，TGY对AP的作用是通过TGY对交感血管运动活性的作用实现的。
