Lu G W, Miura K, Yukimura T, Yamamoto K
Department of Pharmacology, Osaka City University Medical School, Japan.
J Ethnopharmacol. 1994 Apr;42(2):77-82. doi: 10.1016/0378-8741(94)90100-7.
Clerodendron trichotomum Thunb. is a herb which has been used for treatment of hypertension in Chinese medicine. To assess the action of the herb on blood pressure and renal function, the extract was administered to rats and dogs. Intravenous administration of the extract elicited renal vasodilation and increased urine flow and urinary sodium excretion. Acute oral administration of the extract reduced blood pressure of spontaneously hypertensive rats but not of normotensive control rats. Chronic daily administration for 6 weeks prevented the increase in blood pressure of spontaneously hypertensive rats. These results may give some support to the claim on the clinical efficacy of the extract of Clerodendron trichotomum Thunb.
海州常山是一种在中国医学中用于治疗高血压的草药。为了评估该草药对血压和肾功能的作用，将其提取物给予大鼠和狗。静脉注射该提取物可引起肾血管舒张，并增加尿量和尿钠排泄。急性口服该提取物可降低自发性高血压大鼠的血压，但对正常血压对照大鼠无效。连续6周每日给药可防止自发性高血压大鼠血压升高。这些结果可能为海州常山提取物临床疗效的说法提供一些支持。
