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心脏移植后的第二次分娩——病例研究

A second delivery after heart transplantation - a case study.

作者信息

Kalinka Jarosław, Szubert Maria, Zdziennicki Andrzej, Chojnowski Krzysztof, Maciejewski Marek, Piestrzeniewicz Katarzyna, Zakliczyński Michał, Drożdż Jarosław

机构信息

Department of Perinatology, First Chair of Gynecology and Obstetrics, Medical University of Lodz, Poland.

Department of Surgical and Oncological Gynecology, Medical University of Lodz, Poland.

出版信息

Kardiochir Torakochirurgia Pol. 2014 Sep;11(3):339-42. doi: 10.5114/kitp.2014.45688. Epub 2014 Sep 28.

DOI:10.5114/kitp.2014.45688
PMID:26336446
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4283883/
Abstract

Pregnancy after organ transplantation is becoming relatively common. We present the case of a heart transplant recipient who gave birth to a second child. Despite the fact that the transplanted heart seems to adapt well to the changes caused by pregnancy, gestation in patients after heart transplantation may be complicated by hypertension, pre-eclampsia, or preterm labor. In this article, we consider the issues of preterm uterine contractions, anemia, thrombocytopenia, and several other complications in pregnant patients with transplanted hearts. We also present current opinions regarding the use of glucocorticoids as a form of preventing breathing disorders in neonates as well as breast-feeding by mothers receiving immunosuppressive agents. Pregnancies in heart transplant recipients should be considered high-risk. A second successful delivery of a healthy child remains a challenge for such patients and their doctors.

摘要

器官移植后怀孕正变得相对常见。我们介绍了一位心脏移植受者生下第二个孩子的病例。尽管移植的心脏似乎能很好地适应怀孕引起的变化,但心脏移植患者的妊娠可能会并发高血压、先兆子痫或早产。在本文中,我们探讨了心脏移植孕妇的早产宫缩、贫血、血小板减少症及其他几种并发症问题。我们还介绍了关于使用糖皮质激素预防新生儿呼吸障碍以及接受免疫抑制剂治疗的母亲进行母乳喂养的当前观点。心脏移植受者的妊娠应被视为高危妊娠。此类患者及其医生要再次成功分娩出健康婴儿仍是一项挑战。

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A second delivery after heart transplantation - a case study.心脏移植后的第二次分娩——病例研究
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[Heart transplantations: impact on female fertility].[心脏移植:对女性生育能力的影响]
Bull Acad Natl Med. 1991 Apr;175(4):531-40; discussion 540-5.
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Anesthesia management for cesarean section 10 years after heart transplantation: a case report.心脏移植术后10年剖宫产的麻醉管理:一例病例报告。
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本文引用的文献

1
Pregnancy-related human leukocyte antigen sensitization leading to cardiac allograft vasculopathy and graft failure in a heart transplant recipient: a case report.妊娠相关人类白细胞抗原致敏导致心脏移植受者发生心脏移植血管病变和移植物衰竭:一例报告
Transplant Proc. 2013 Mar;45(2):800-2. doi: 10.1016/j.transproceed.2012.10.038.
2
Pregnancy after cardiac transplantation.心脏移植后的妊娠。
Cardiol Clin. 2012 Aug;30(3):441-52. doi: 10.1016/j.ccl.2012.05.001.
3
Rethinking EuroSCORE - how can we redefine surgical risk to diminish intraoperative complications.重新审视欧洲心脏手术风险评估系统(EuroSCORE)——我们如何重新定义手术风险以减少术中并发症。
Kardiol Pol. 2010 Jan;68(1):130.
4
Severe facial clefts in acrofacial dysostosis: a consequence of prenatal exposure to mycophenolate mofetil?肢端面部发育不全中的严重面部裂隙:产前接触霉酚酸酯的后果?
Obstet Gynecol. 2008 Feb;111(2 Pt 2):483-6. doi: 10.1097/01.AOG.0000298347.18812.a4.
5
Immunosuppressant therapy in pregnant organ transplant recipients.妊娠器官移植受者的免疫抑制治疗
Semin Perinatol. 2007 Dec;31(6):363-71. doi: 10.1053/j.semperi.2007.09.006.
6
Pregnancy after organ transplantation: a report from the UK Transplant pregnancy registry.器官移植后的妊娠:来自英国移植妊娠登记处的报告。
Transplantation. 2007 May 27;83(10):1301-7. doi: 10.1097/01.tp.0000263357.44975.d0.
7
Breastfeeding during tacrolimus therapy.他克莫司治疗期间的母乳喂养。
Obstet Gynecol. 2006 Feb;107(2 Pt 2):453-5. doi: 10.1097/01.AOG.0000164052.66219.c7.
8
Pregnancy in heart transplant recipients.心脏移植受者的妊娠情况。
J Heart Lung Transplant. 2004 Jul;23(7):898-901. doi: 10.1016/j.healun.2003.08.002.
9
Pro- and anti-cancer effects of immunosuppressive agents used in organ transplantation.器官移植中使用的免疫抑制剂的抗癌和促癌作用。
Transplantation. 2004 Jun 27;77(12):1777-82. doi: 10.1097/01.tp.0000120181.89206.54.
10
Pregnancy outcome after cyclosporine therapy during pregnancy: a meta-analysis.孕期环孢素治疗后的妊娠结局:一项荟萃分析。
Transplantation. 2001 Apr 27;71(8):1051-5. doi: 10.1097/00007890-200104270-00006.