Georgiev G, Avgarska S, Savov I, Eksperova D
Akush Ginekol (Sofiia). 1989;28(6):6-9.
The influence of betamethasone (celestone) was studied on the fetal lung development in pregnant rats of Wistar strain. It was shown that the drug was without effect, administered singly. After treatment of the pregnant rats for a period of 3 days with a dose of 0.100 mg/kg the content of the lung surfactant in their amniotic fluids was increased, manifested by an elevation of the threshold dilution (TD), determined by the method of the black foam film. Administration of two-fold higher dose did not cause quicker synthesis of surfactant. The morphological examination of the fetal lung showed that celestone accelerated the synthesis, maturation and secretion of surfactant and intensified differentiation of prealvelocytes of I and II types after the 18th day of the fetal development, which occurred a day earlier than in the control rats.
研究了倍他米松（塞来松）对Wistar品系怀孕大鼠胎儿肺发育的影响。结果表明，单独给药时该药物无作用。以0.100mg/kg的剂量对怀孕大鼠进行3天的治疗后，其羊水表面活性物质的含量增加，表现为通过黑色泡沫膜法测定的阈值稀释度（TD）升高。给予两倍高的剂量并未导致表面活性物质更快合成。胎儿肺的形态学检查表明，在胎儿发育第18天后，塞来松加速了表面活性物质的合成、成熟和分泌，并增强了I型和II型前肺泡细胞的分化，这比对照大鼠提前一天发生。
