Georgiev G, Avgarska S
Akush Ginekol (Sofiia). 1989;28(4):24-6.
The authors treated in advance two groups of pregnant rats of Wistar strain with indomethacin in doses of 3 mg/kg of body mass and 5 mg/kg of body mass for a period of 2 days. Then the animals were killed on 18th, 19th and 20th day of gestation and the change in the lung surfactant of amniotic fluid was determined by the method of the black foam film. There was threshold dilution in both groups of treated rats in comparison with the control group. They found changes in the gastrointestinal tract of the mother and fetus death of some fetuses after larger parenteral administration of larger dose of indomethacin. An inference is made for the negative effect of indomethacin on lung maturation.
作者以3mg/kg体重和5mg/kg体重的剂量，用吲哚美辛对两组Wistar品系怀孕大鼠进行了为期2天的预处理。然后在妊娠第18、19和20天处死动物，采用黑泡沫膜法测定羊水肺表面活性物质的变化。与对照组相比，两组处理后的大鼠均出现阈值稀释。他们发现，较大剂量吲哚美辛经肠道外较大剂量给药后，母体胃肠道发生变化，部分胎儿死亡。由此推断吲哚美辛对肺成熟有负面影响。
