Yang Qing, Guo Qi-Hao, Bi Yan-Chao
Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China.
CNS Neurosci Ther. 2015 Oct;21(10):784-92. doi: 10.1111/cns.12449. Epub 2015 Sep 4.
Semantic dementia (SD) is a neurodegenerative disorder characterized by the progressive loss of semantic memory and conceptual knowledge, coupled with asymmetric local brain atrophy concentrated in the anterior temporal lobe. Recent developments in neuroimaging techniques, especially the emergence of the "human connectomics," have made possible the study of the brain's functional and structural connections and the topological properties of the brain networks. Recent studies applying these techniques have shown that SD manifests extensive structural and functional connectivity alterations, providing important insights into the pathogenesis of SD and the neural basis of semantic memory in general. In this review, we present and discuss the existing findings about the brain connectivity changes in SD and how they might be related to the various behavioral deficits associated with this disorder and propose important unanswered questions that warrant further investigation.
语义性痴呆（SD）是一种神经退行性疾病，其特征是语义记忆和概念知识逐渐丧失，同时伴有集中在前颞叶的不对称性局部脑萎缩。神经成像技术的最新进展，尤其是“人类连接组学”的出现，使得研究大脑的功能和结构连接以及脑网络的拓扑特性成为可能。应用这些技术的最新研究表明，语义性痴呆表现出广泛的结构和功能连接改变，这为语义性痴呆的发病机制以及一般语义记忆的神经基础提供了重要见解。在这篇综述中，我们展示并讨论了关于语义性痴呆中脑连接变化的现有发现，以及它们如何与该疾病相关的各种行为缺陷相关联，并提出了有待进一步研究的重要未解决问题。
