Rakhmilevich A L, Obernikhin S S, Rakhimova M S
Antibiot Khimioter. 1989 Nov;34(11):839-41.
Changes in sensitivity of the murine spleen cells to interleukin-2 (IL-2) after exposure to lipopolysaccharide (LPS), muramyldipeptide (MDP) and their combinations were studied. The possible effect of concanavalin A (Con A) administered in vivo on increasing sensitivity of the lymphoid cells to IL-2 was also studied. Exposure to LPS, MDP and their combinations led to an over 2-fold increase in responses of the spleen cells to the effect of IL-2 as compared to the controls. When Con A was administered to mice intravenously in a high dose, sensitivity of their spleen cells to IL-2 markedly increased in 18 hours.
研究了小鼠脾细胞在暴露于脂多糖（LPS）、胞壁酰二肽（MDP）及其组合后对白细胞介素-2（IL-2）敏感性的变化。还研究了体内给予刀豆球蛋白A（Con A）对增加淋巴细胞对IL-2敏感性的可能作用。与对照组相比，暴露于LPS、MDP及其组合导致脾细胞对IL-2作用的反应增加了2倍以上。当以高剂量静脉内给予小鼠Con A时，其脾细胞对IL-2的敏感性在18小时内显著增加。
