Zapuskalova O B, Novitskiĭ V V, Go'ldberg E D
Antibiot Khimioter. 1989 Nov;34(11):855-9.
It was shown in experiments with CBA/Lac J mice that both a single use of doxorubicin (MID) and its use during a treatment course (1/10 LD50.10) induced impairment of the morphological composition of the central and peripheral lymphoid organs along with changes in the functional activity of separate cell populations of the immune system which persisted over a prolonged period up to 3 months. The course use of the drug resulted in a significant decrease in the proliferative response of the splenocytes to the polyclonal T- and B-cell mitogens in 1 month, which was followed by inhibition of interleukin-2 production. On the contrary, 1 month later, the single administration of the cytostatic induced activation of the LPS-responding cell populations and an increase in production of the growth factor in the culture of T-lymphocytes.
在对CBA/Lac J小鼠进行的实验中发现，单次使用阿霉素（MID）及其在一个疗程（1/10 LD50.10）中的使用，都会导致中枢和外周淋巴器官的形态组成受损，同时免疫系统中各个细胞群体的功能活性也会发生变化，这些变化会持续很长时间，长达3个月。该药物的疗程使用导致1个月时脾细胞对多克隆T细胞和B细胞有丝分裂原的增殖反应显著降低，随后白细胞介素-2的产生受到抑制。相反，1个月后，单次给予细胞抑制剂会诱导LPS反应性细胞群体的激活，并使T淋巴细胞培养物中生长因子的产生增加。
