癌症干细胞疫苗的前景。
Promise of cancer stem cell vaccine.
作者信息
Zhou Li, Lu Lin, Wicha Max S, Chang Alfred E, Xia Jian-chuan, Ren Xiubao, Li Qiao
机构信息
a Comprehensive Cancer Center; University of Michigan ; Ann Arbor , MI USA.
b Department of Biotherapy ; Tianjin University Cancer Institute and Hospital; National Clinical Research Center of Cancer; Key Laboratory of Cancer Immunology and Biotherapy ; Tianjin , China.
出版信息
Hum Vaccin Immunother. 2015;11(12):2796-9. doi: 10.1080/21645515.2015.1083661.
Dendritic cell (DC)-based vaccines designed to target cancer stem cells (CSC) can induce significant antitumor responses via conferring host anti-CSC immunity. Our recent studies have demonstrated that CSC-DC vaccine could inhibit metastasis of primary tumors and induce humoral immune responses against cancer stem cells. This approach highlights the promise of cancer stem cell vaccine in cancer immunotherapy.
旨在靶向癌症干细胞（CSC）的基于树突状细胞（DC）的疫苗可通过赋予宿主抗CSC免疫力来诱导显著的抗肿瘤反应。我们最近的研究表明，CSC-DC疫苗可抑制原发性肿瘤的转移并诱导针对癌症干细胞的体液免疫反应。这种方法凸显了癌症干细胞疫苗在癌症免疫治疗中的前景。
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