Cancer Discov. 2015 Nov;5(11):OF4. doi: 10.1158/2159-8290.CD-NB2015-127. Epub 2015 Sep 3.
Burkitt lymphoma is unusually common in parts of Africa where malaria is widespread, but the reason for the association has been unclear. A new study suggests that parasitic infection triggers dramatic B-cell proliferation and increased expression of the enzyme activation-induced cytidine deaminase, which generates more potent antibodies-and causes mutations that lead to cancer.
伯基特淋巴瘤在疟疾广泛流行的非洲部分地区非常常见，但这种关联的原因尚不清楚。一项新的研究表明，寄生虫感染会引发戏剧性的 B 细胞增殖，并增加激活诱导的胞苷脱氨酶的表达，从而产生更有效的抗体，并导致导致癌症的突变。
