Komaki Hisayuki, Ichikawa Natsuko, Hosoyama Akira, Fujita Nobuyuki, Igarashi Yasuhiro
Biological Resource Center, National Institute of Technology and Evaluation (NBRC), Chiba 292-0818, Japan
NBRC, Tokyo 151-0066, Japan.
FEMS Microbiol Lett. 2015 Oct;362(20). doi: 10.1093/femsle/fnv155. Epub 2015 Sep 3.
We report the draft genome sequence of marine-derived Streptomyces sp. TP-A0882, a producer of buryrolactol, an antifungal γ-lactone-containing polyketide. The genome harbored at least three type I polyketide synthase (PKS), three type II PKS, four nonribosomal peptide synthetase (NRPS) and two hybrid PKS/NRPS gene clusters. Annotation of gene functions enabled us to identify the type I PKS gene cluster for butyrolactol biosynthesis and propose a plausible biosynthetic pathway for this unique polyketide.
我们报道了海洋来源的链霉菌属菌株TP-A0882的基因组序列草图，该菌株是含抗真菌γ-内酯的聚酮化合物丁内酯的生产者。该基因组包含至少三个I型聚酮合酶（PKS）、三个II型PKS、四个非核糖体肽合成酶（NRPS）和两个杂合PKS/NRPS基因簇。基因功能注释使我们能够鉴定出丁内酯生物合成的I型PKS基因簇，并为这种独特的聚酮化合物提出一个合理的生物合成途径。
