Esposito Susanna, Cerutti Marta, Milani Donatella, Menni Francesca, Principi Nicola
a Pediatric Highly Intensive Care Unit, Department of Pathophysiology and Transplantation , Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico , Milan , Italy.
Hum Vaccin Immunother. 2016 Mar 3;12(3):801-5. doi: 10.1080/21645515.2015.1086046.
Despite the fact that the achievement of appropriate immunization coverage for routine vaccines is a priority for health authorities worldwide, vaccination delays or missed opportunities for immunization are common in children with chronic diseases. The main aim of this cross-sectional study was to evaluate immunization coverage and the timeliness of vaccination in children suffering from 3 different rare genetic diseases: Rubinstein-Taybi syndrome (RSTS), Sotos syndrome (SS), and Beckwith-Wiedemann syndrome (BWS). A total of 57 children with genetic diseases (15 with RSTS, 14 children with SS, and 28 with BWS) and 57 healthy controls with similar characteristics were enrolled. The coverage of all the recommended vaccines in children with genetic syndromes was significantly lower than that observed in healthy controls (p < 0.05 for all the comparisons). However, when vaccinated, all of the patients, independent of the genetic syndrome from which they suffer, were administered the primary series and the booster doses at a similar time to healthy controls. In comparison with parents of healthy controls, parents of children with genetic diseases were found to more frequently have negative attitudes toward vaccination (p < 0.05 for all the comparisons), mainly for fear of the emergence of adverse events or deterioration of the underlying disease. This study shows that vaccination coverage is poor in pediatric patients with RSTS, BWS, and SS and significantly lower than that observed in healthy children. These results highlight the need for educational programs specifically aimed at both parents and pediatricians to increase immunization coverage in children with these rare genetic diseases.
尽管实现常规疫苗的适当免疫覆盖率是全球卫生当局的首要任务，但慢性病患儿中疫苗接种延迟或错过免疫接种机会的情况很常见。这项横断面研究的主要目的是评估患有3种不同罕见遗传病的儿童的免疫覆盖率和疫苗接种及时性：鲁宾斯坦-泰比综合征（RSTS）、索托斯综合征（SS）和贝克威思-维德曼综合征（BWS）。共纳入了57名患有遗传病的儿童（15名患有RSTS，14名患有SS，28名患有BWS）和57名具有相似特征的健康对照。患有遗传综合征的儿童中所有推荐疫苗 的覆盖率显著低于健康对照（所有比较p<0.05）。然而，在接种疫苗时，所有患者，无论患有何种遗传综合征，接种基础免疫系列疫苗和加强剂量疫苗的时间与健康对照相似。与健康对照的父母相比，患有遗传病的儿童的父母对疫苗接种的负面态度更为常见（所有比较p<0.05），主要是担心出现不良事件或基础疾病恶化。这项研究表明，患有RSTS、BWS和SS的儿科患者的疫苗接种覆盖率较低，且显著低于健康儿童。这些结果凸显了需要针对父母和儿科医生开展专门的教育项目，以提高这些罕见遗传病患儿的免疫覆盖率
