Novell E L, Rodrigues N L, Bianchi G S, Ribas B O
Bol Estud Med Biol. 1989 Jul-Dec;37(3-4):95-9.
The present study was designed to investigate the effects of nickel chloride on dietary iron deficiency in rats. The degree of iron deficiency was relatively moderate, but a more generalized anemia occurred in iron deficiency, in absence of nickel chloride. Moderate iron deficiency anemia induced increased lactate-dehydrogenase activity of serum and bone marrow, perhaps related to the decreased production of energy by oxidative means. Nickel chloride, perhaps for its ability to change iron absorption, for the maintenance of bone marrow metabolism and for to increase ceruloplasmin activity, inhibited the alteration on hemoglobin synthesis. Furthermore, nickel chloride possibly for its action on copper content and Cu-Zn superoxide-dismutase activity, inhibits the shortening of the red cell life span, caused by superoxide radicals.
本研究旨在探讨氯化镍对大鼠膳食缺铁的影响。缺铁程度相对适中，但在没有氯化镍的情况下，缺铁时会出现更普遍的贫血。中度缺铁性贫血导致血清和骨髓乳酸脱氢酶活性增加，这可能与氧化方式产生能量减少有关。氯化镍可能因其改变铁吸收的能力、维持骨髓代谢的能力以及增加铜蓝蛋白活性的能力，抑制了血红蛋白合成的改变。此外，氯化镍可能因其对铜含量和铜锌超氧化物歧化酶活性的作用，抑制了超氧自由基导致的红细胞寿命缩短。
