Adamson J
New York Blood Center, New York, NY 10021, USA.
Semin Hematol. 1996 Apr;33(2 Suppl 2):5-7; discussion 8-9.
Erythropoietin (EPO) plays a central role in the regulation of red blood cell (RBC) production. Since iron is an essential element for erythropoiesis and hemoglobin (Hb) synthesis, its importance is heightened in patients treated with epoetin alfa. Stimulation of erythropoiesis following the administration of epoetin alfa is associated with several changes in iron metabolism; indeed, plasma ferritin levels fall as a result of increased utilization of iron by the expanding erythroid marrow. The administration of epoetin alfa can therefore lead to a state of relative iron deficiency. Thus, iron supplementation is essential to maximize the effect of epoetin alfa-induced erythropoiesis.
促红细胞生成素（EPO）在调节红细胞（RBC）生成过程中发挥核心作用。由于铁是红细胞生成和血红蛋白（Hb）合成的必需元素，在接受阿法依泊汀治疗的患者中其重要性更为突出。给予阿法依泊汀后红细胞生成的刺激与铁代谢的若干变化相关；实际上，随着不断扩大的红系骨髓对铁的利用增加，血浆铁蛋白水平会下降。因此，给予阿法依泊汀可导致相对缺铁状态。所以，补充铁剂对于最大化阿法依泊汀诱导的红细胞生成效果至关重要。
