McWhite Claire D, Liebeskind Benjamin J, Marcotte Edward M
Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, & Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, United States.
Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, & Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, United States.
Curr Opin Genet Dev. 2015 Dec;35:16-24. doi: 10.1016/j.gde.2015.08.004. Epub 2015 Sep 4.
Direct comparison of human diseases with model phenotypes allows exploration of key areas of human biology which are often inaccessible for practical or ethical reasons. We review recent developments in comparative evolutionary approaches for finding models for genetic disease, including high-throughput generation of gene/phenotype relationship data, the linking of orthologous genes and phenotypes across species, and statistical methods for linking human diseases to model phenotypes.
将人类疾病与模型表型进行直接比较，有助于探索人类生物学的关键领域，这些领域往往因实际或伦理原因而难以触及。我们回顾了在寻找遗传疾病模型的比较进化方法方面的最新进展，包括高通量生成基因/表型关系数据、跨物种直系同源基因和表型的关联，以及将人类疾病与模型表型相联系的统计方法。
