Nadeem Amina, Mumtaz Sadaf, Naveed Abdul Khaliq, Aslam Muhammad, Siddiqui Arif, Lodhi Ghulam Mustafa
Department of Physiology, Army Medical College, National University of Sciences and Technology, Rawalpindi, Pakistan.
Department of Physiology, College of Medicine, University of Dammam, Kingdom of Saudi Arabia.
J Pak Med Assoc. 2015 Sep;65(9):928-32.
To study the pattern of dyslipidaemia in Type 2 Diabetes Mellitus patients and to determine the correlation of increasing age and duration of the disease with dyslipidaemia, insulin level and insulin resistance in diabetic patients.
The cross-sectional case-control study was conducted at Combined Military Hospital, Rawalpindi, and Centre for Research in Experimental and Applied Medicine, Army Medical College, Rawalpindi, Pakistan from June 2011 to June 2012, and comprised patients of type 2 diabetes mellitus and healthy controls. Serum levels of total cholesterol, triglycerides, low density lipoprotein, high-density lipoprotein and insulin in both the cases and the controls. Insulin resistance was calculated by Homeostatic Model of Assessment of insulin resistance. Correlation between increasing age and duration of the disease was determined using biochemical parameters. SPSS 17 was used for statistical analysis.
Of the 112 subjects in the study, 72(64%) were patients and 40(36%) were healthy controls. Among the cases, hypertriglyceridaemia was the commonest in 44(61%) followed by low-density-lipoprotein-hypercholesterolaemia 36(50%). Among the controls, 20(50%) subjects had low-density-lipoprotein-hypercholesterolaemia, followed by hypertriglyceridaemia in 17(42.5%). Duration of the disease was not found to be correlated with dyslipidaemia or insulin resistance (p>0.05). There was strong negative correlation of duration of the disease with serum insulin levels (p=0.03). Age showed no significant correlation with dyslipidaemia, serum insulin levels or insulin resistance on regression analysis (p>0.05 each).
In type diabetes mellitus, hypertriglyceridaemia was the commonest dyslipidaemia whereas hypercholesterolaemia was a risk factor in healthy individuals. Besides, the duration of disease was inversely correlated with serum insulin levels and positively correlated with dyslipidaemia.
研究2型糖尿病患者血脂异常模式，并确定糖尿病患者年龄增长和病程与血脂异常、胰岛素水平及胰岛素抵抗之间的相关性。
2011年6月至2012年6月在巴基斯坦拉瓦尔品第联合军事医院和拉瓦尔品第陆军医学院实验与应用医学研究中心进行了一项横断面病例对照研究，研究对象包括2型糖尿病患者和健康对照者。检测了病例组和对照组的血清总胆固醇、甘油三酯、低密度脂蛋白、高密度脂蛋白和胰岛素水平。采用胰岛素抵抗稳态模型评估法计算胰岛素抵抗。利用生化参数确定年龄增长与病程之间的相关性。采用SPSS 17进行统计分析。
本研究的112名受试者中，72名（64%）为患者，40名（36%）为健康对照者。在病例组中，高甘油三酯血症最为常见，有44名（61%），其次是低密度脂蛋白高胆固醇血症，有36名（50%）。在对照组中，20名（50%）受试者有低密度脂蛋白高胆固醇血症，其次是高甘油三酯血症，有17名（42.5%）。未发现病程与血脂异常或胰岛素抵抗相关（p>0.05）。病程与血清胰岛素水平呈强负相关（p=0.03）。回归分析显示，年龄与血脂异常、血清胰岛素水平或胰岛素抵抗均无显著相关性（各p>0.05）。
在2型糖尿病中，高甘油三酯血症是最常见的血脂异常，而高胆固醇血症是健康个体的一个危险因素。此外，病程与血清胰岛素水平呈负相关，与血脂异常呈正相关。
