Bashir Farhat, Khan Zia Ullah, Seetlani Naresh Kumar, Sheikh Zaman
Department of Medicine, United Medical & Dental College, Karachi, Pakistan.
Sir Syed College of Medical Sciences, Karachi, Pakistan.
J Ayub Med Coll Abbottabad. 2017 Oct-Dec;29(4):604-609.
Macrovascular atherosclerosis is an important long-term complication of type 2 diabetes mellitus. Concurrent dyslipidaemia acts as an additional risk factor for these complications. Hypovitaminosis D has been associated with adverse cardiovascular events. These modifiable risk factors of cardiovascular disease are inter-related. In the presence of an increasing incidence of type 2 diabetes mellitus and its associated metabolic abnormalities and widespread vitamin D deficiency in Pakistan, this association needs to be investigated. The purpose of our study was to determine the pattern of dyslipidaemia and its association with low vitamin D levels in South Asian diabetics.
The study was designed as a quantitative cross-sectional study. It was conducted at the Department of Medicine, Sir Syed College of Medical Sciences and Hospital, Karachi from January to June 2014. A total of 168 adult consecutive patients with type 2 diabetes mellitus of both the genders were included. Data was collected and analysed using SPSS-20.0. The association of dyslipidaemia with vitamin D status was computed through Chi-square test.
We found that dyslipidaemia is highly prevalent in patients with type 2 diabetes mellitus in Pakistan. High total cholesterol, LDL cholesterol and triglycerides show significant association with vitamin D deficiency.
In order to decrease the development of diabetic complications aggressive management of hyperglycaemia and dyslipidaemia is required. Vitamin D supplementation may play a dual role in these situations.
大血管动脉粥样硬化是2型糖尿病的一种重要长期并发症。并存的血脂异常是这些并发症的额外危险因素。维生素D缺乏与不良心血管事件相关。这些心血管疾病的可改变危险因素相互关联。鉴于巴基斯坦2型糖尿病及其相关代谢异常的发病率不断上升以及维生素D普遍缺乏，有必要对这种关联进行研究。我们研究的目的是确定南亚糖尿病患者血脂异常的模式及其与低维生素D水平的关联。
本研究设计为定量横断面研究。于2014年1月至6月在卡拉奇赛义德爵士医学科学学院和医院内科进行。共纳入168例连续的成年2型糖尿病患者，男女不限。使用SPSS-20.0收集和分析数据。通过卡方检验计算血脂异常与维生素D状态的关联。
我们发现血脂异常在巴基斯坦2型糖尿病患者中非常普遍。高总胆固醇、低密度脂蛋白胆固醇和甘油三酯与维生素D缺乏显著相关。
为了减少糖尿病并发症的发生，需要积极控制高血糖和血脂异常。在这些情况下，补充维生素D可能发挥双重作用。
